نتایج جستجو برای: drosha

تعداد نتایج: 598  

2016
Mi Na Kim Jung Oh Kim Seung Min Lee Hana Park Ju Ho Lee Kyu Sung Rim Seong Gyu Hwang Nam Keun Kim

Single-nucleotide polymorphisms (SNPs) in microRNA machinery genes might affect microRNA processing and subsequently impact tumorigenesis. The aim of this study was to investigate the associations between SNPs in microRNA machinery genes and hepatocellular carcinoma (HCC) in a Korean population. Genotyping of six SNPs in microRNA machinery genes was performed using blood samples from 147 patien...

2014
Elixabet López-López Ángela Gutiérrez-Camino Maria Ángeles Piñán José Sánchez-Toledo Jose Javier Uriz Javier Ballesteros Purificación García-Miguel Aurora Navajas África García-Orad

Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated the relationship between genetic variation and treatment-related toxicity. However, most of these studies are focused in coding regions. Nowadays, it is known that regions t...

2016
Luqing Zhao Yitao Mao Yuelong Zhao Yanong He

DDX3X, located on the X-chromosome, belongs to the DEAD-box RNA helicase family and acts as a key RNA-binding protein to exert its regulatory functions in various biological processes. In this paper, knock-down the expression of DDX3X can affect a subset of miRNA expression levels, especially for miR-1, miR-141, miR-145, miR-19b, miR-20a and miR-34a. Through adopting the immunoprecipitation (IP...

Journal: :Proceedings of the National Academy of Sciences 2011

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