Sequencing pathogen genomes is costly, demanding careful allocation of limited sequencing resources. We built a computational Sequencing Analysis Pipeline (SAP) to guide decisions regarding the amount of genomic sequencing necessary to develop high-quality diagnostic DNA and protein signatures. SAP uses simulations to estimate the number of target genomes and close phylogenetic relatives (near ...

Next-generation genomic technology has both greatly accelerated the pace of genome research as well as increased our reliance on draft genome sequences. While groups such as the Genomics Standards Consortium have made strong efforts to promote genome standards there is a still a general lack of uniformity among published draft genomes, leading to challenges for downstream comparative analyses. ...

Recent advances in both clone fingerprinting and draft sequencing technology have made it increasingly common for species to have a bacterial artificial clone (BAC) fingerprint map, BAC end sequences (BESs) and draft genomic sequence. The FPC (fingerprinted contigs) software package contains three modules that maximize the value of these resources. The BSS (blast some sequence) module provides ...

Domain Name System (DNS) protocol extensions have been defined to authenticate the data in DNS and provide key distribution services (draft-ietf-dnssec-secext-10.txt). DNS Dynamic Update operations have also been defined (draft-ietf-dnsind-dynDNS-*.txt>, but without a detailed description of strong security for the update operation. This draft describes how to use DNS digital signatures coverin...

Internet Drafts are draft documents valid for a maximum of six months. Internet Drafts may be updated, replaced, or obsoleted by other documents at any time. It is not appropriate to use Internet Drafts as reference material or to cite them other than as a ''working draft'' or ''work in progress''. To learn the current status of any Internet-Draft, please check the 1id-abstracts.txt listing con...

This draft document is being circulated for comment. Please send your comments to the authors or to the mhtml mail list . If consensus is reached, this Access Type may be registered with IANA and this document may be submitted to the RFC editor as an Informational protocol specification. Internet Drafts are draft documents valid for a maximum of six months. They may be up...

DomainKeys" creates a domain-level authentication framework for email by using public key technology and the DNS to prove the provenance and contents of an email. This document defines a framework for digitally signing email on a per-domain basis. The ultimate goal of this framework is to unequivocally prove and protect identity while retaining the semantics of Internet email as it is known tod...