Research in the near future involves the integration of multi-functional nanodevices into selfcontained nanosystems with capabilities of sensing, controlling, communicating and actuating/responding. A nanosystem is composed not only of nanodevices but also a nanopower-source (or nano-battery). But the small size of the nano-battery significantly limits the battery lifetime. It is highly desirab...

Development of highly sensitive and selective sensing systems of divalent zinc ion (Zn(2+)) in organisms has been a growing interest in the past decades owing to its pivotal role in cellular metabolism, apoptosis, and neurotransmission. Herein, we report the rational design and synthesis of a Zn(2+) fluorescent-based probe by assembling lanthanide-doped upconversion nanoparticles (UCNPs) with c...

Polymeric delivery systems based on nanoparticles have emerged as a promising approach for peroral insulin delivery. The aim of the present study was to investigate the release of insulin nanoparticulate systems and ex vivo studies. The nanoparticles were prepared by the ion gelation method. Particle size distribution, zeta potential, and polydispersity index of the nanoparticles were determine...

A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(la...

Rational design and construction of delivery nanosystems for anticancer metal complexes is a crucial strategy to improve solubility under physiological conditions and permeability and retention behavior in tumor cells. Therefore, in this study, we designed and synthesize a transferrin (Tf)-conjugated nanographene oxide (NGO) nanosystem as a cancer-targeted nanocarrier of Pt complexes (Tf-NGO@Pt...

PEGylation in polymeric nanomedicine has gained substantial predominance in biomedical applications due to its resistance to protein absorption, which is critically important for a therapeutic delivery system in blood circulation. The shielding layer of PEGylation, however, creates significant steric hindrance that negatively impacts cellular uptake and intracellular distribution at the target ...

Fluorescent metal nanoclusters (NCs) have given rise to a new class of fluorescent nanomaterials for the detection of heavy metals. Here, we design a simple, rapid and highly sensitive sensing nanosystem for the detection of Hg2+ and Cu2+ based on fluorescence quenching of ultrasmall DNA-Ag NCs. The fluorescence intensity of DNA-Ag NCs was selectively quenched by Hg2+ and Cu2+, and the limit of...

auctions have been as a competitive method of buying and selling valuable or rare items for a long time. single-sided auctions in which participants negotiate on a single attribute (e.g. price) are very popular. double auctions and negotiation on multiple attributes create more advantages compared to single-sided and single-attribute auctions. nonetheless, this adds the complexity of the auctio...

conclusion this study shows no significant improvement in the cancer detection rate by double reading; however, a lower recall rate could be a more helpful consequence. results readers had consensus on bi-rads categories in 459 breasts (71%), but diverse categories were used for 183 breasts (29%), including 132 significant and 51 non-significant discrepancies. according to weighted kappa test, ...

abstract background and aims. the aim of this study was to evalute the effect of double pedicle graft (dpg) with and without plasma rich in growth factor (prgf) in the treatment of miller's cl i and ii gingival recessions. materials and methods. thirty two bilateral buccal gingival miller’s cl i and ii recessions were selected. sixteen of the recessions were treated with dpg and prgf (test grou...