one small-scale double emulsion technique for incorporation of naja- naja oxiana venom into poly (lactide-co-glycolide) (plga) microspheres were developed and optimized. the effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and in vitro release of venom were studied. a stable double emulsion was verified by homogenization method. slow...

background postoperative pain is considered as a reason of patient’s delay in discharge and disability aggravation. therefore, multimodal approaches have been suggested in order to mitigate pain and decrease postoperative side effects. objectives the aim of this study was to evaluate analgesic effect of a single dose injection of dexamethasone on reducing postoperative pain in laparoscopic chol...

BACKGROUND/AIMS An acute immunological stress reaction was previously reported to occur after the painful setting of retrobulbar anaesthesia before intraocular surgery. This study was conducted to find out whether an oral low dose premedication with midazolam would modify the immunological stress reaction. METHODS 32 patients undergoing intraocular surgery using retrobulbar anaesthesia were i...

A total number of 88 fishes Thai pangas were conducted for induced spawning experiments. Among them, 30 mature Pangasius sutchi were conducted for the length-weight relationship, 25 matured females for the fecundity and 33 fishes (12 males and 21 females) for induced spawning experiments. The total-standard length relationship curve shows a straight line with a strong correlation (r = 0.986 and...

A total number of 88 fishes Thai pangas were conducted for induced spawning experiments. Among them, 30 mature Pangasius sutchi were conducted for the length-weight relationship, 25 matured females for the fecundity and 33 fishes (12 males and 21 females) for induced spawning experiments. The total-standard length relationship curve shows a straight line with a strong correlation (r = 0.986 and...

A study of the cell kinetics on the actively growing periosteal surface of the femur of rabbits aged 2 weeks has been continued. A single injection of tritiated thymidine was given and the rabbits killed from 1 hour to 4 days after injection. The grain count spectra of the different cell types, pre-osteoblast, osteoblast, and osteocyte, have been compared at different times after injection. The...

We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study. A control group (n = 110) and a nafamostat (n = 103) group received 5% glucose 0.02 ml kg-1 and nafamostat 0.02 mg kg-1 diluted with 5% glucose, respectively, followed 1 min later by 1% propofol injected at a rate of 200 mg min-1. Pain ...

PURPOSE To compare pain on injection of two modified anesthetic lidocaine solutions for use in upper blepharoplasty: 2% lidocaine with 1:100,000 epinephrine, and 2% lidocaine with 1:100,000 epinephrine buffered 9:1 with 8.4% sodium bicarbonate. METHODS In this prospective, double-masked study, 25 consecutive patients undergoing upper blepharoplasty were submitted to the anesthesic procedure. ...

OBJECTIVE To see if the alkalinisation of lignocaine caused a reduction in the pain of injection for digital nerve blockade. METHODS The study was a prospective randomised double blind study with each patient acting as their own control. During the study period, all patients aged 16 years and over presenting to the accident and emergency department with a condition requiring digital nerve blo...