BACKGROUND AND PURPOSE For the first time, delivered dose to the rectum has been calculated and accumulated throughout the course of prostate radiotherapy using megavoltage computed tomography (MVCT) image guidance scans. Dosimetric parameters were linked with toxicity to test the hypothesis that delivered dose is a stronger predictor of toxicity than planned dose. MATERIAL AND METHODS Dose-s...

Material and Methods: From 2006-2013 801 patients with early stage NSCLC were treated with CBCT guided SBRT (median 54 Gy in 3 fractions) in 5 institutes for whom treatment plans were available. 565 patients were analyzed after exclusion of synchronous or metachronous tumors (n=80), follow-up<1y (n=63), or death from cancer (93).An average anatomy was constructed based on 109 patients of the 5 ...

The recent popularity of permanent implants for treatment of prostate cancer has created a large demand for low energy seed sources. Vendors have introduced new source designs to meet this demand. The AAPM has recommended that all low energy interstitial brachytherapy seed sources be subjected to independent dosimetric evaluations, preferably using experimental measurements as well as Monte Car...

This study evaluated the incidence of hepatic toxicity after stereotactic ablative radiotherapy (SABR) using 3 fractions to the liver, and identified the predictors for hepatic toxicity. We retrospectively reviewed 78 patients with primary and metastatic liver cancers, who underwent SABR using 3 fractions between 2003 and 2011. To examine the incidence of hepatic toxicity, we defined newly deve...

PURPOSE The incidence of sensorineural hearing loss (SNHL) after treatment with combination of intensity-modulated radiation therapy (IMRT) and cisplatin-based chemotherapy in nasopharyngeal carcinoma (NPC) patients was evaluated, and relationships of SNHL with host factors, treatment-related factors, and radiation dosimetric parameters were investigated. METHODS Fifty-one NPC patients treate...

BACKGROUND AND PURPOSE New treatment techniques in radiotherapy employ increasing dose calculation complexity in treatment planning. For an adequate check of the results coming from a modern treatment planning system, clinical tools with almost the same degree of generality and accuracy as the planning system itself are needed. To fulfil this need we propose a photon pencil kernel parameterizat...

BACKGROUND To assess the relationship between dosimetric parameters and the quality of life (QL) outcomes of patients with low-intermediate-risk localised prostate cancer (LPC) treated with low-dose-rate brachytherapy (LDR-BT). MATERIALS AND METHODS We evaluated the participants in two consecutive prospective studies of the QL of patients treated with LDR-BT for LPC. QL was evaluated by means...

PURPOSE A major concern in prostate brachytherapy is rectal toxicity, which mainly depends on the dose and volume of rectum involved by radiation. We hypothesize that the rectal distension, as produced by constipation, influences the dosimetric parameters of the rectum and other pelvic organs. MATERIAL AND METHODS An open, controlled, prospective, paired trial (pre-post test) was designed and...

In this study, dose rate distribution around a spherical 137Cs pellet source, from a low-dose-rate (LDR) Selectron remote afterloading system used in gynecological brachytherapy, has been determined using experimental and Monte Carlo simulation techniques. Monte Carlo simulations were performed using MCNP4C code, for a single pellet source in water medium and Plexiglas, and measurements were pe...

Dosimetric modeling of radiation transport in skeletal bone tissues using computational phantoms provides the doses internal exposure to active marrow. Computational ICRP are created for reference people with anatomical and physiological characteristics typical an average individual. The calculated such will correspond certain population-average values. Individual variability introduce a stocha...