Case history A 73 year old lady was referred with a four week history of proximal muscle weakness, myalgia and an erythematous, oedematous rash aVecting her face, upper chest, and back. Systemic enquiry and general examination was otherwise unremarkable. Initial investigations revealed a normal full blood count, erythrocyte sedimentation rate, C reactive protein, urea and electrolytes, liver fu...

STI571 (imatinib) is increasingly being used in the treatment of different phases of chronic myeloid leukemia and metastatic gastrointestinal stromal tumors.1,2 Philadelphia-positive acute lymphoblastic leukemia (Ph ALL) has a poor prognosis with the current treatment options.3 Allogenic stem cell transplantation is the only curative management option available to date, the long-term survival b...

Introduction: Apple peel is rich in many bioactive compounds and has been studied for its beneficial effects protective role multiple disorders, but effect on blood cells bone marrow needs to be investigated.
 Aims & Objectives: To determine the of apple extract peripheral prednisolone treated mice.
 Place duration study: Pharmacology Department Post Graduate Medical Institute Pat...

BACKGROUND Oral corticosteroids used in short courses for acute asthma are regarded as safe, although the frequent use of these drugs may result in patients suffering from systemic side effects. It has become common practice for patients to increase their own inhaled corticosteroid intake when their asthma goes out of control, but it has never been established whether a high dose of inhaled cor...

We report a case of organizing pneumonia (OP) that developed after radiation therapy (RT) for breast cancer. A 54-year-old woman presented with malaise and fever within a month after the completion of RT for breast cancer. Chest radiographs and computed tomography (CT) demonstrated consolidation in the left upper lobe consistent with radiation pneumonia. The patient was given 60 mg/day IV corti...

BACKGROUND Prednisolone is a major risk factor for hyperglycaemia and new-onset diabetes after transplantation. Uncontrolled observational data suggest that divided dosing may reduce requirements for hypoglycaemic agents. This study aims to compare the glycaemic effects of divided twice daily (BD) and once daily (QD) prednisolone. METHODS Twenty-two kidney transplant recipients without diabet...

Idiopathic nephrotic syndrome, although a rare disease, is the most common primary glomerular disease among children. It causes substantial morbidity because it typically runs a relapsing course punctuated with prolonged periods of corticosteroids and other immunosuppressive medication. It affects about 2 children per 100,000 aged ,16 years in Europe and North America, with higher rates reporte...

a 3-year-old girl was presented with periorbital edema, hypertension, proteinuria, and hematuria. she recovered clinically after 9 days with normal urinalysis. during the follow-up, she developed recurrent episodes of nephrotic syndrome. the kidney biopsy revealed mild mesangial proliferation and a low dose of prednisolone could effectively control the disease. iran j med sci 2005; 30(1): 38-40...