BACKGROUND Roughly 20% of patients in hospital have impaired kidney function. This is frequently overlooked because of the creatinine-blind range in which early stages of renal failure are often hidden. Chronic kidney disease is divided into 5 stages (CKD 1 to 5). METHODS Selective literature search. RESULTS Methotrexate, enoxaparin and metformin are examples of drugs that should no longer ...

heavy metal contamination in the environment could cause harmful effects both to human health and aquatic life. numerous remediation methods had been developed to encounter with the contamination problem prior to degrade, decrease and to purify the contaminated water at minimal concentration as low as possible. therefore, in current study, commercialized chicken eggshells and hybrid akar putra ...

Objectives To build a lamotrigine (LTG) physiologically based pharmacokinetic (PBPK) model (LTG PBPK) and compare it to the clinical data from South Asian Indian patients use this understand drug interactions of LTG explore optimal doses. Methods Material The PBPK was developed using PK-Sim software platform qualified with plasma concentration an study. European population database chosen as pa...

The theoretical model of emotion regulation and many empirical findings have suggested that children's emotion regulation may mediate the association between parents' emotion socialization and children's psychological adjustment. However, limited research has been conducted on moderators of these relations, despite the argument that the associations between parenting practices and children's ps...

RATIONALE Busulfan (Bu) is an important component of the myeloablative conditioning regimen prior to hematopoietic stem cell transplantation (HSCT) especially in children. Intravenously administered Bu exhibits a therapeutic window phenomenon requiring therapeutic drug monitoring. Analytical methods developed for Bu routine monitoring were aimed at using low volumes of biological fluids and dev...

Tanshinol has desirable antianginal and pharmacokinetic properties and is a key compound of Salvia miltiorrhiza roots (Danshen). It is extensively cleared by renal excretion. This study was designed to elucidate the mechanism underlying renal tubular secretion of tanshinol and to compare different ways to manipulate systemic exposure to the compound. Cellular uptake of tanshinol was mediated by...

Tanshinol has desirable antianginal and pharmacokinetic properties and is a key compound of Salvia miltiorrhiza roots (Danshen). It is extensively cleared by renal excretion. This study was designed to elucidate the mechanism underlying renal tubular secretion of tanshinol and to compare different ways to manipulate systemic exposure to the compound. Cellular uptake of tanshinol was mediated by...

Children's social and emotional adjustment at age 8 were examined in relation to attachment security, parenting style, setting conditions, and social and emotional adjustment at age 4. Seventy-nine children participated in videotaped interaction sessions with their mothers and with unfamiliar peers at the two ages. Data were derived from videotape coding, mother questionnaires, and child sociom...

OBJECTIVE This study examines the moderating influence of rural residence on the associations between health locus of control (HLC) beliefs and psychological well-being. METHOD Two hundred and twenty-four breast cancer patients were surveyed. RESULTS The results revealed that rurality interacted with HLC beliefs in predicting psychological adjustment. The pattern indicated that, whereas end...

BACKGROUND Experiencing potentially traumatic events is associated with psychological distress. However, some survivors also experience positive personal and psychological changes in the aftermath of trauma. METHODS The present study investigated perceived posttraumatic growth in 197 ministerial employees who were present at work during the 2011 Oslo bombing attack. The relationships between ...