نتایج جستجو برای: dopamine agonist

تعداد نتایج: 91054  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Christopher P Ford Gregory P Mark John T Williams

The mesolimbic dopamine system, which mediates the rewarding properties of nearly all drugs of abuse, originates in the ventral tegmental area (VTA) and sends major projections to both the nucleus accumbens (NAc) and the basolateral amygdala (BLA). To address whether differences occur between neurons that project to these separate areas, retrograde microspheres were injected to either the BLA o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Michael M Torrice Kiowa S Bower Henry A Lester Dennis A Dougherty

We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug-receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic acetylcholine receptor and the D2 dopamine receptor. Receptors were expressed in Xenopus oocytes, and activation of a G protein-coupled, inwar...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
JianPing Wu John J Hablitz

Layer I of the neocortex comprises axonal processes from widespread regions of the brain and a unique population of GABAergic interneurons. Dopamine is known to directly depolarize layer I interneurons, but the underlying mechanism is unclear. Using whole-cell recording techniques in neocortical brain slices, we have examined how dopamine increases excitability of layer I interneurons in postna...

Journal: :Journal of the neurological sciences 2010
Paolo Solla Alfonso Fasano Antonino Cannas Francesco Marrosu

OBJECTIVES To report and characterize a dopamine agonist (DA) withdrawal syndrome (DAWS) in Parkinson disease. DESIGN Retrospective cohort study. SETTING Outpatient tertiary movement disorders clinic. Patients A cohort of 93 nondemented patients with Parkinson disease enrolled in a prospective study of nonmotor and motor disease manifestations. Main Outcome Measure The presence of DAWS, def...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Jorge D Brioni Robert B Moreland Marlon Cowart Gin C Hsieh Andrew O Stewart Petter Hedlund Diana L Donnelly-Roberts Masaki Nakane James J Lynch Teodozyi Kolasa James S Polakowski Mark A Osinski Kennan Marsh Karl-Erik Andersson James P Sullivan

Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here we report that the dopamine D(4) receptor plays a role in the regulation of penile function. ABT-724 is a selective dopamine D(4) receptor agonist t...

Journal: :Journal of neurochemistry 2006
Demian Barbas Jacques P Zappulla Stéphane Angers Michel Bouvier Habib A Mohamed John H Byrne Vincent F Castellucci Luc DesGroseillers

In Aplysia, the neurotransmitter dopamine is involved in the regulation of various physiological processes and motor functions, like feeding behaviour, and in the siphon-gill withdrawal reflex. In this paper, we report the characterization of the first Aplysia D1-like dopamine receptor (Apdop1) mainly expressed in the CNS, heart and buccal mass. Following expression of the Apdop1 receptor in HE...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1994
S L Atkin E A Masson L D Blumhardt M C White

The cases are reported of two patients who developed benign intracranial hypertension after the withdrawal of the novel non-ergot derived dopamine agonist CV 205 502 (quinagolide).

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Thomas S Hnasko Bethany N Sotak Richard D Palmiter

Rodents learn to associate the rewarding effects of drugs with the environment in which they are encountered and, subsequently, will display a conditioned place preference (CPP) for that environment. Cocaine-induced CPP is generally thought to be mediated through inhibition of the dopamine transporter and the consequent increase in extracellular dopamine. However, here we report that dopamine-d...

2009
Heinz Reichmann

“Parkinson’s disease (PD) doesn’t kill you, it takes your life away.” This is a disturbing quotation by the English Parkinson Lay Organisation. There is, however, no other neurodegenerative disease which responds better to treatment than PD. Treatment of advanced PD is located between these poles (Figure 1). Most national guidelines and papers on the treatment of PD recommended that early phase...

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