The present research work aims to demonstrate the effectiveness of the new methodology of Design of Dynamic Experiments (DoDE) in optimizing an important pharmaceutical reaction. An easily developed response surface model (RSM) is used instead of a hard to develop knowledge-driven process model. The DoDE approach allows the experimenter to introduce dynamic factors in the design, which during t...

The U.S. Department of Energy (DOE) has recently implemented a series of strategic initiatives to address long-term radiological surveillance needs at former U.S. test sites in the Marshall Islands. The plan is to engage local atoll communities in developing shared responsibilities for implementing radiation protection programs for resettled and resettling populations. As part of this new initi...

In planar OLED structures, a signifi cant fraction of the internal light emission is trapped in guided modes. This trapped light is a major limitation on the external quantum effi ciency, and a number of studies have integrated photonic microstructures into OLEDs to improve the device effi ciency by extracting trapped light such as the substrate modes, [ 3 ] the waveguide modes [ 4 ] and the su...

The aim of this review is to give insight into the reproduction potential of the Boer goat doe. Assessment of the reproduction traits in the Boer goat doe demonstrates a mean body weight at puberty of between 30.6 and 27.5kg, depending on the dietary energy level. Kids weaned during the natural breeding season (April/May) exhibit oestrus or puberty earlier than those weaned outside the natural ...

In presented paper a design model is developed which is used to find an optimal design space in order to improve precision and accuracy of reversed 3D models. Significant parameters and their mutual effects in scanning process are recognized with the help of Design of Experiments (DOE) principles, and in second step recognized significant parameters are also optimized using the RSM (Response Su...

To solve problems that exist in optimal design such as falling into local optimal solution easily and low efficiency in multi-objective optimization, a new approach based on design of experiments (DOE) and gradient optimization (GO) was proposed. The new optimization method is called DPG (DOE Plus GO) which used DOE for preliminary analysis of the function model, and took the optimal values obt...

We introduce a design of experiments (DOE) methodology to the optimization of a-SiO2 structures using classical molecular dynamics (MD) simulations. This approach produces defect-free systems in good agreement with experimental results of radial distribution functions and angular distribution functions. Application of DOE techniques allows systematic development of optimal MD simulation sequenc...

OBJECTIVE The right to vote can be abrogated when persons become incompetent to cast a ballot. This applies particularly to people with Alzheimer's disease, who at some point will lose capacity. A 2001 federal court decision offered the first clear criteria ("Doe voting capacity standard") for determining voting competence, focused on understanding the nature and effect of voting and on the abi...

Formulating appropriate storage conditions for biopharmaceutical proteins is essential for ensuring their stability and thereby their purity, potency, and safety over their shelf-life. Using a model murine IgG3 produced in a bioreactor system, multiple formulation compositions were systematically explored in a DoE design to optimize the stability of a challenging antibody formulation worst case...

Fecal corticosterone concentration (FCC) is increasingly being used as a noninvasive indicator of stress in assessment of nonhuman animal welfare. The aim of this study was to evaluate effects of breed, cage type, reproductive phase, and their interactions on FCC levels in doe rabbits. A total of 252 doe rabbits were randomly assigned to 2 groups. Does were individually housed in either standar...