HCN and its isomer HNC play an important role in molecular cloud chemistry the formation of more complex molecules. We investigate here impact protostellar shocks on abundances from high-sensitivity IRAM 30m observations prototypical shock region L1157-B1 envelope associated Class 0 protostar, as a proxy for pre-shock gas. The isotopologues H$^{12}$CN, HN$^{12}$C, H$^{13}$CN, HN$^{13}$C, HC$^{1...

Resistance to anthracyclines and other chemotherapeutics due to P-glycoprotein (pgp)-mediated export is a frequent problem in cancer treatment. Here, we report that iron oxide-titanium dioxide core-shell nanocomposites can serve as efficient carriers for doxorubicin to overcome this common mechanism of drug resistance in cancer cells. Doxorubicin nanocarriers (DNC) increased effective drug upta...

BACKGROUND Dental stem cells in combination with implant materials may become an alternative to autologous bone transplants. For tissue engineering different types of soft and rigid implant materials are available, but little is known about the viability and the osteogenic differentiation of dental stem cells on these different types of materials. According to previous studies we proposed that ...

Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription factor c-Jun are important regulators of this cell death program in post-mitotic neurons following survival-factor withdrawal. Our study demonstrate...

Ultrathin multilayers are important for electrical and optical devices, as well as for immunoassays, artificial organs, and for controlling surface properties. The construction of ultrathin multilayer films by electrostatic layer-by-layer deposition proved to be a popular and successful method to create films with a range of electrical, optical, and biological properties. Dendrimer nanocomposit...

The 2004 US Presidential Election cycle marked the debut of Internet-based media such as blogs and social networking websites as institutionally recognized features of the American political landscape. Using a longitudinal sample of all DNC/RNC-designated blog-citation networks we are able to test the influence of various strategic, institutional, and balance-theoretic mechanisms and exogenous ...

We report on molecular abundances and distributions in a starless dense core L492. We have found that the abundances of carbon-chain molecules such as CCS, C3S, HC3N, HC5N, and HC7N are comparable to those in chemically young dark cloud cores called ”carbon-chain–producing regions”, such as L1495B, L1521B, L1521E, and TMC-1. This is the first dark cloud core with extremely rich in carbon-chain-...

Huge amounts of rich context social network data are generated everyday from various applications such as FaceBook and Twitter. These data involve multiple social relations which are community-driven and dynamic in nature. The complex interplay of these characteristics poses tremendous challenges on the users who try to understand the underlying patterns in the social media. We introduce an exp...

Background: New psychoactive substances (NPS) have become a global phenomenon, with over 134 countries and territories from all world regions reporting them. Since December 2021, governments, laboratories, partner agencies confirmed to the UNODC Early Warning Advisory (EWA) on NPS 1124 substances. It is agreed that control one of most challenging tasks for developing countries. Identifying pres...