Strand displacement and tile assembly systems are designed to follow prescribed kinetic rules (i.e., exhibit a specific time-evolution). However, the expected behavior in the limit of infinite time—known as thermodynamic equilibrium—is often incompatible with the desired computation. Basic physical chemistry implicates this inconsistency as a source of unavoidable error. Can the thermodynamic e...

Sequence design has turned out to be a crucial factor in successful DNA computing. In this paper, we present a support system for sequence design in DNA computing. Our system can fit various requirements for sequence design. The β-version of this software is available for download.

Latent fingerprints are commonly recovered from crime scenes using tape lifts. Advancements in the sensitivity of DNA testing allow for DNA profiles from these “touch”, tape lift samples to be obtained. One drawback to DNA typing of tape lifts is that the adhesive material on the tape may inhibit DNA recovery. The purpose of this study was to maximize the recovery of DNA from the adhesive mater...

Introduction: The Mitochondrion and Its Genome ............................................................ 1 The Human Mitochondrial Genome ................................................................................... 3 The D-loop and Human Population Genetics ..................................................................... 4 Mitochondrial DNA and Recent Human History .................

Mitochondrial DNA (mtDNA) has been used as a tool for forensic identification since 1993 (1,2). It has now become widely accepted, its US courtroom debut being reported in both the scientific and popular press (3-5). Perhaps the greatest utility of mtDNA analysis in a forensic context is in the field of hair comparison. MtDNA can give valuable objective evidence where only subjective judgements...

There is increasing interest in gene-specific repair studies. This aspect of DNA repair is currently under intense investigation and new laboratories are entering the field. The data are coming in rapidly and we are in the midst of exciting developments. Accordingly, it is premature to build extensive models of the regulation and biological importance of gene specific repair. The purpose of thi...

The purpose of this article is to introduce a data visualization technique for class cover catch digraphs which allows for the discovery of latent subclasses. We illustrate the technique via a pedagogical example and an application to data sets from arti5cial nose chemical sensing and gene expression monitoring by DNA microarrays. Of particular interest is the discovery of latent subclasses rep...