Knowledge of lead's capacity to disrupt the prooxidant/antioxidant balance within mammalian tissues suggests that definitive therapy for chronic lead poisoning should encompass both chelating and antioxidant actions. The dithiol meso-2,3-Dimercaptosuccinic Acid (DMSA) is the first orally administered metal chelating agent to receive U.S. Food and Drug Administration (FDA) approval for the treat...

BACKGROUND This study was undertaken to determine the incidence of urinary tract infection (UTI) and the frequency of anatomical abnormalities in newborns with unexplained jaundice and to find out if there is any correlation between bilirubin level and renal damage. METHODS We studied 462 full-term neonates for UTI. They were aged 3-25 days, with either high (>10 mg/dL) or prolonged (>10 days...

Forty-seven patients with unilateral obstructive calculi (12 males and 35 females) were submitted to 99mTc-diethylene triamine pentaacetic acid (DTPA) or 99mTc-dimercaptosuccinic acid (DMSA) scans for assessment of renal function. The scans revealed unilateral functional deficit in 68 and 66% of the patients, respectively. A calculus size of 1.1 to 2.0 cm was significantly associated with defic...

abstract background: screening for patients at risk of renal scarring is a challenge in children with acute pyelonephritis (apn). diuretic tc-99m mercaptoacetyltriglycine (mag3) scintigraphy with zero time injection of furosemide (mag3-f0) was observed to display focal parenchymal disorders. the advantages of mag3 include: lower radiation dose and short duration of the test. the aim of this stu...

Received 2/5/2003; revised 6/13/2003; accepted 6/17/2003. For correspondence or reprints contact: Bi-Fang Lee, M.D., Department of Nuclear Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. Tel: (886)6-2766109, Fax: (886)6-2766609, E-mail: [email protected] Introduction: It is often difficult, especially in children, to accurately diagnose acute pyelo...

Abstract The magnetic properties of magnetite nanoparticles (Fe 3 O 4 NPs) strongly depend on their chemical and physical parameters, which can be regulated by a controlled synthesis process. To improve the quality obtained nanoparticles, surface is often modified with organic compounds (from group surfactants, sugars, proteins, or acid). In this study, we synthesized compound DMSA. Then, nanoc...

background: recently, applications of nanoparticles in many fields of medicine have been developed, due to their specific physical and chemical properties. therefore assessment of their toxicity specially in the in vivo condition is necessary. objectives: the aim of this study is to evaluation the effect of fe3o4 nanoparticles coating by biocompatible compounds on their toxicity and also compar...

Objective: The purpose of this study was to determine if volume-rendered three-dimensional displays could improve the accuracy of reporting renal cortical scars in patients imaged with mTc dimercaptosuccinic acid (DMSA). Methods: We compared volume-rendered three-dimensional displays of SPECT data for 20 patients, with a total of 37 kidneys, with SPECT data displayed as transaxial, coronal and ...

Two chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and sodium 2,3-dimercapto-propane-1-sulphonate (DMPS) were tested for their efficiency in mercury removal from the body of rats in the presence and in the absence of selenium. Female Wistar rats were given a single intraperitoneal injection of mercuric chloride or an equimolar mixture of mercuric chloride and sodium selenite (1.5 micr...

This study aimed to evaluate if the splenectomy alters the biodistribution of 99mTc-DMSA and renal function in Wistar rats. The animals were separated in the groups: splenectomy (n = 6) and control (n = 6). After splenectomy (15 days), the administration of 0.1ml of 99mTc-DMSA IV (0.48 MBq) was carried out. Thirty minutes later, kidney, heart, lung, thyroid, stomach, bladder and femur and sampl...