The imprinting of the genes on human chromosome 11p15.5 is thought to be controlled by two imprinting control regions located in two differentially methylated CpG islands upstream of the H19 gene (H19 DMR) and in intron 10 of the KCNQ1 gene (KvDMR). We have examined sequences in the human 11p15.5 genomic imprinted region for the presence of insulators and silencers using a position- and enhance...

We investigate the Gaussianity of the 4-year COBE-DMR data (in HEALPix pixelisation) using an analysis based on spherical Haar wavelets. We use all the pixels lying outside the Galactic cut and compute the skewness, kurtosis and scale-scale correlation spectra for the wavelet coefficients at each scale. We also take into account the sensitivity of the method to the orientation of the input sign...

Electronic documents on the Internet are always generated with many kinds of side information. Although those massive kinds of information make the analysis become very difficult, models would fit and analyze data well if they could make full use of those kinds of side information. This paper, base on the study on probabilistic topic model, proposes a new improved LDA model which is suitable fo...

Current technologies for studying ion channels are fundamentally limited because of their inability to functionally link ion channel activity to cellular pathways. Herein, we report the use of label-free cell phenotypic profiling to decode the composition and signaling of an endogenous ATP-sensitive potassium ion channel (KATP) in HepG2C3A, a hepatocellular carcinoma cell line. Label-free cell ...

Sheep is an important livestock in the world for meat, dairy and wool production. The third version of sheep reference genome has been recently assembled, but sheep DNA methylome has not been profiled yet. In this study, we report the comprehensive sheep methylome with 94.38% cytosine coverage at single base resolution by sequencing DNA samples from Longissimus dorsi of dizygotic Sunit sheep, w...

Although there has been a demarcation between development and evolution (maintenance) of software, this is increasingly irrelevant as fewer and very fewer systems are completely new. Additionally, once a software engineer understands a system's structure, it is difficult to preserve this understanding, because the structure tends to change during maintenance. So Software engineers greatly empha...

The article discusses the development of an instrument complex (bench, stand) for study digital radio communication standards: APCO P25, DMR and TETRA, based on software-defined systems (SDR) technologies in voice mode. bench is HackRF One broadband SDR transceiver GNU Radio open software toolkit. Along with One, it proposed to use TV tuner AstroMeta Digital Dongle as available receiver. struct...

There is a growing need for fast, highly sensitive and quantitative technologies to detect and profile unaltered cells in biological samples. Technologies in current clinical use are often time consuming, expensive, or require considerable sample sizes. Here, we report a diagnostic magnetic resonance (DMR) sensor that combines a miniaturized NMR probe with targeted magnetic nanoparticles for de...