CADTH recommends that Vabysmo be reimbursed by public drug plans for the treatment of diabetic macular edema (DME) if certain conditions are met.
 should covered to treat patients with DME provided it is a similar patient population and in way other anti–vascular endothelial growth factor (VEGF) drugs currently adult DME.
 only prescribed an ophthalmologist experience managing ...

PURPOSE To assess changes in choroidal thickness in type 2 diabetic patients with diabetic retinopathy (DR) and diabetic macular edema (DME) using enhanced-depth imaging spectral domain optical coherence tomography (EDI-OCT). METHODS Among 235 eyes from 145 patients, 195 treatment-naïve eyes were divided into no DR, mild/moderate nonproliferative DR (NPDR), severe NPDR, proliferative DR (PDR)...

BACKGROUND Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinica...

This paper presents a new discriminative language model based on the whole-sentence maximum entropy (ME) framework. In the proposed discriminative ME (DME) model, we exploit an integrated linguistic and acoustic model, which properly incorporates the features from n-gram model and acoustic log likelihoods of target and competing models. Through the constrained optimization of integrated model, ...

In this paper, we analyze the feasibility of indoor broadband service provisioning using secondary spectrum access to the 960-1215 MHz band, primarily allocated to the distance measuring equipment (DME) system for aeronautical navigation. We propose a practical secondary sharing scheme customized to the characteristics of the DME. Since the primary system performs a safety-of-life functionality...

PURPOSE To review the most important metabolic effects and clinical safety data of subthreshold micropulse diode laser (D-MPL) in diabetic macular edema (DME). METHODS Review of the literature about the mechanisms of action and role of D-MPL in DME. RESULTS The MPL treatment does not damage the retina and is selectively absorbed by the retinal pigment epithelium (RPE). MPL stimulates secret...

Diabetic macular edema (DME) remains an important cause of visual loss. Although anti-vascular endothelial growth factor (VEGF) agents are generally used as first-line treatments for patients with center-involving DME, there is an important role for corticosteroids as well. Corticosteroids may be especially useful in pseudophakic patients poorly responsive to anti-VEGF therapies, in patients wi...

Diabetic macular edema (DME) is a leading cause of blindness in the working population. Herein, we report the case of a patient with recurrent DME for about 6 years, uncontrolled by several medical and surgical treatments, that was successfully treated with a single sustained-release fluocinolone acetonide intravitreal implant in her right eye. The affected eye had presented a visual acuity of ...

Treatment of an alkaline earth metal (Ca, Sr, Ba) with 2,4,6-trimethylphenol (HOmes) at elevated temperatures in the presence of mercury under solvent-free conditions, followed by extraction of the reaction mixture with 1,2-dimethoxyethane (dme), afforded dinuclear alkaline earth aryloxo complexes [Ae2(Omes)4(dme)4] (Ae = Ca 1, Sr 3, Ba 6). Extraction of the Ca metal and HOmes reaction mixture ...

In Focus • THE JOURNAL OF CELL BIOLOGY H ikers and migrating embryonic cells need to know their location so they can eventually reach their destination. Laplante and Nilson (1) reveal that some epidermal cells in the Drosophila embryo fi nd out where they are from their neighbors. Although it looks almost ready to hatch, a late-stage Drosophila embryo still has a gaping hole in its back. The op...