نتایج جستجو برای: dmd

تعداد نتایج: 4377  

Journal: :Journal of computational physics 2011
Md. Ashfaquzzaman Khan Martin C. Herbordt

Discrete molecular dynamics simulation (DMD) uses simplified and discretized models enabling simulations to advance by event rather than by timestep. DMD is an instance of discrete event simulation and so is difficult to scale: even in this multi-core era, all reported DMD codes are serial. In this paper we discuss the inherent difficulties of scaling DMD and present our method of parallelizing...

Journal: :The Lancet. Neurology 2018
David J Birnkrant Katharine Bushby Carla M Bann Benjamin A Alman Susan D Apkon Angela Blackwell Laura E Case Linda Cripe Stasia Hadjiyannakis Aaron K Olson Daniel W Sheehan Julie Bolen David R Weber Leanne M Ward

A coordinated, multidisciplinary approach to care is essential for optimum management of the primary manifestations and secondary complications of Duchenne muscular dystrophy (DMD). Contemporary care has been shaped by the availability of more sensitive diagnostic techniques and the earlier use of therapeutic interventions, which have the potential to improve patients' duration and quality of l...

Journal: :Neuromuscular disorders : NMD 1996
G Bedogni L Merlini A Ballestrazzi S Severi N Battistini

Body hydration and extra- to intra-cellular water ratio (ECW: ICW) have been studied in 12 duchenne muscular dystrophy (DMD) patients and 15 healthy controls. Subjects underwent total body water (TBW) and extracellular water (ECW) assessment by deuterium and bromide dilution, respectively. Multifrequency bioelectric impedance analysis (MFBIA) was performed on all subjects with the aim to establ...

Journal: :Internal medicine 2008
Hitoshi Mochizuki Satoko Miyatake Mikiya Suzuki Toshiki Shigeyama Kana Yatabe Katsuhisa Ogata Takuhisa Tamura Mitsuru Kawai

OBJECTIVE This study investigated the relationship between mental retardation and lifetime events in patients with Duchenne muscular dystrophy (DMD). METHODS The data on mental retardation and ages of lifetime events (first walking, loss of ambulation, introductions of ventilator support and tube nutrition and death) were collected retrospectively, and the relationships between the factors we...

Journal: :The American Journal of Human Genetics 2005

Journal: :Journal of medical genetics 1981
M Zatz A M Vianna-Morgante P Campos A J Diament

A female with Duchenne muscular dystrophy who was a carrier of a balanced translocation t(X;6)(p21;q21) is reported. Four other previously described (X;A) translocations associated with DMD share with the present case a breakpoint at Xp21. The extremely low probability of five independent (X;A) translocations having a breakpoint at Xp21 points to a non-rand association of this site with the DMD...

2017
V. Marrocco P. Fiore A. Benedetti S. Pisu E. Rizzuto A. Musarò L. Madaro B. Lozanoska-Ochser M. Bouché

Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a severe muscle disease caused by a mutation in the dystrophin gene. We previously showed that genetic ablation of Protein Kinase C θ (PKCθ) in mdx, the mouse model of DMD, improves muscle healing and regeneration, preventing massive inflammation. To establish whether pharmacological targeting of PKC...

2018
Courtney A. Bishop Valeria Ricotti Christopher D. J. Sinclair Matthew R. B. Evans Jordan W. Butler Jasper M. Morrow Michael G. Hanna Paul M. Matthews Tarek A. Yousry Francesco Muntoni John S. Thornton Rexford D. Newbould Robert L. Janiczek

Subjects with Duchenne Muscular Dystrophy (DMD) suffer from progressive muscle damage leading to diaphragmatic weakness that ultimately requires ventilation. Emerging treatments have generated interest in better characterizing the natural history of respiratory impairment in DMD and responses to therapy. Dynamic (cine) Magnetic Resonance Imaging (MRI) may provide a more sensitive measure of dia...

Journal: :Molecular human reproduction 1999
N D Hussey H Donggui D A Froiland D J Hussey E A Haan C D Matthews J E Craig

We have developed five conventional duplex polymerase chain reaction (PCR) protocols on single lymphocytes and blastomeres from embryos, in order to analyse five exons commonly deleted in deletion-type Duchenne muscular dystrophy (DMD). The five DMD gene exons (17, 19, 44, 45 and 48) can be analysed in separate duplex PCR reactions together with the sex-determining region Y (SRY) gene which ena...

Journal: :Journal of medical genetics 1993
C Holding D Bentley R Roberts M Bobrow C Mathew

In order to develop and validate methods for the preimplantation diagnosis of Duchenne muscular dystrophy (DMD), we have established and evaluated PCR assays for the analysis of four loci within the DMD gene and for two Y chromosome sequences in single cells. A model system using buccal cells picked from mouthwash samples has been used for an extensive evaluation of the sensitivity and specific...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید