β-Diketone antibiotics (DKAs) can produce chronic toxicity in aquatic ecosystems due to their pseudo-persistent in the environment. In this study, after long-term DKA exposure to zebrafish (Danio rerio), 47 protein spots had greater than 2-fold differential expression as compared to the control; there were 26 positive proteins with 14 up-regulated and 12 down-regulated. The main functions of th...

OBJECTIVE This study was designed to examine the efficacy and risk of bicarbonate administration in the emergent treatment of severe acidemia in diabetic ketoacidosis (DKA). METHODS PUBMED database was used to identify potentially relevant articles in the pediatric and adult DKA populations. DKA intervention studies on bicarbonate administration versus no bicarbonate in the emergent therapy, ...

OBJECTIVE The study aimed to evaluate the pre-treatment and post-treatment oxidant capacity, antioxidant capacity and S100B protein levels in cases of diabetic ketoacidosis (DKA). METHODS The study included 49 pediatric patients diagnosed with DKA and a control group comprising 49 healthy children. Blood samples were obtained after confirmation of the DKA diagnosis and also after treatment. S...

The intralobular distribution of metabolism was examined in the livers from rats with severe diabetic ketoacidosis (DKA), perfused at pH 6.8, and compared with that in livers from normal starved animals perfused at either pH 7.4 or 6.8. With lactate and palmitate as substrates, the perivenous uptake of periportally synthesized glucose seen in normal livers at pH 7.4 was abolished during DKA; in...

Diabetic ketoacidosis (DKA) is a medical emergency with multi-organ complications. Venous thromboembolism (VTE) is a rare complication of DKA. We are presenting a 58 year old male patient with poorly controlled type 2 diabetes mellitus who was hospitalized with DKA secondary to noncompliance. His clinical picture was complicated by generalized thrombosis involving multiple venous locations incl...

BACKGROUND Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two serious, preventable complications of diabetes mellitus. Analysis of variables associated with recurrent DKA and HHS admission has the potential to improve patient outcomes by identifying possible areas for intervention. The aim of this study was to evaluate potential predictors of recurrent DKA or HHS adm...

We present the CT, MR, and autopsy findings of central brain herniation in a 9-year-old boy undergoing treatment for diabetic ketoacidosis (DKA). Severe cerebral edema resulting in central brain herniation is an uncommon complication of the treatment of DKA but carries with it high morbidity and mortality. Radiologic imaging and autopsy findings in this case revealed striking infarctions of cen...

Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes. It is characterized by the biochemical triad of hyperglycemia, ketonemia/ ketonuria, and an increased anion gap (AG) metabolic acidosis. Unless it is relatively mild, DKA is usually managed in the intensive care unit (ICU), and treatment involves a continuous infusion of intravenous (IV) insulin, c...

BACKGROUND: Diabetic ketoacidosis (DKA) is a life-threatening endocrine emergency, traditionally requiring arterial blood gas (ABG) analysis for diagnosis and monitoring. The aim of our study was to assess the comparability of arterial and venous blood samples for pH and bicarbonate measurements in patients with DKA. MATERIALS AND METHODS: Prospective, observational study of patients with suspe...