To better understand methodological factors that alter landings strategies, we compared sagittal plane joint energetics during the initial landing phase of drop jumps (DJ) vs. drop landings (DL), and when shod vs. barefoot. Surface electromyography, kinematic and kinetic data were obtained on 10 males and 10 females during five consecutive drop landings and five consecutive drop jumps (0.45m) w...

and Applied Analysis 3 the multivalued projection for K; (2) ∇g ⋆ (] 󸀠 ) ∈ K : ⟨∇g ⋆ (] 󸀠 ) − x, ∇g ⋆ (ω 󸀠 )

G enetic forms of Parkinson’s disease (PD) are useful in helping us to understand the underlying pathophysiology of this disorder in both its rare familial forms and the more common ‘‘sporadic’’ type. Three genes are unambiguously causal in different PD families: -synuclein, parkin, and DJ-1 (reviewed in ref. 1). Two recessive mutations have been found in DJ-1, a large deletion and an L166P poi...

Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor suppressor in HCT116 cells. The legumain activity is also increased under acid conditions in Alzheime...

Pigs are ideal organ donors for xenotransplantation and an excellent model for studying human diseases, such as neurodegenerative disease. Transcription activator-like effector nucleases (TALENs) are used widely for gene targeting in various model animals. Here, we developed a strategy using TALENs to target the GGTA1, Parkin and DJ-1 genes in the porcine genome using Large White porcine fibrob...

Mutations in several genes, including Parkin, PTEN-induced kinase 1 (Pink1) and DJ-1, are associated with rare inherited forms of Parkinson's disease (PD). Despite recent attention on the function of these genes, the interplay between DJ-1, Pink1 and Parkin in PD pathogenesis remains unclear. In particular, whether these genes regulate mitochondrial control pathways in neurons is highly controv...

In this paper we study a random graph with N nodes, where node j has degree Dj and{Dj}j=1 are i.i.d. with P(Dj ≤ x) = F (x). We assume that 1 − F (x) ≤ cx for some τ > 3and some constant c > 0. This graph model is a variant of the so-called configuration model,and includes heavy tail degrees with finite variance.The minimal number of edges between two arbitrary connected nod...

DJ-1, the product of a causative gene of a familial form of Parkinson disease, undergoes preferential oxidation of Cys106 (cysteine residue at position 106) under oxidative stress. Using specific monoclonal antibodies against Cys106 oxidized DJ-1 (oxDJ-1), we examined oxDJ-1 immunoreactivity in brain sections from DJ-1 knockout and wild-type mice and in human brain sections from cases classifie...

We have previously reported that reading-frame usage and functional diversification is developmentally regulated, with virtually all TCRB DJ mRNA transcripts using a single reading frame at 8 weeks of gestational age, tapering to 50% by adult life. We used the polymerase chain reaction to create genomic libraries of DJ rearrangements in the TCRB locus from thymuses at 7.7, 10, and 16 weeks of g...