BACKGROUND Ultrafiltration for heart failure may reduce costs associated with acute heart failure by decreasing rehospitalization rates compared to intravenous diuretics. METHODS AND RESULTS We developed a decision-analytic model to explore the clinical outcomes and associated costs of ultrafiltration compared to intravenous diuretics for index and subsequent acute heart failure hospitalizati...

Volume overload is an important clinical target in heart failure management, typically addressed using loop diuretics. An important and challenging subset of heart failure patients exhibit fluid overload despite significant doses of loop diuretics. One approach to overcome loop diuretic resistance is the addition of a thiazide-type diuretic to produce diuretic synergy via "sequential nephron bl...

G out is a monosodium urate crystal deposition disease. Formation of the crystals requires high serum uric acid levels; the local factors responsible for their predilection for the joints are only started to be grasped. 2 Steady serum urate levels result from the balance between its production and excretion; hyperuricaemia results when formation is increased or difficulties in (mostly) renal ex...

I tion alone accounted for this and whether the reduction would have been greater had the diuretics not caused a ‘‘backlash’’ of cardiotoxicty. Certainly, the introduction of orally available thiazide diuretics in 1957–8 revn November 1985, we reviewed the then current status of experimental and clinical evidence and opinion on diuretic-associated hypokalemia with particular attention to its po...

Systolic time intervals, stroke volume, cardiac output and (dZ/dt)/RZ index were serially estimated in 51 normal healthy volunteers at sea level, for ten days after air induction to 3658 m altitude and on return to sea level. The subjects were divided into three groups and were administered a diuretic, beta methyidigoxin and placebo in a double blind protocol. The group on placebo showed an inc...

Diuretics continue to be among the commonest of all prescribed items. Until recently, the physician needed to have little concern about the dose of the agent he was choosing because firstly, the dose-response curve tended to be startlingly flat, and secondly, there was little chance of inducing an excessive diuresis, regardless of dose. Now that furosemide (Lasix) and ethacrynic acid (Edecrin) ...