Consider an experiment in which 10 subjects receive a placebo, and another 10 receive an experimental diuretic. After 8 h, the average urine output in the placebo group is 769 mL, versus 814 mL in the diuretic group—a difference of 45 mL (Figure 1). How do we know if that difference means the drug works and is not just a result of chance? of 45 mL in the average urine output between groups unde...

UNLABELLED Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. METHODS We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging result...

s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...

Polyscias fruticosa (L.) Harm (Family: Araliaceae) is possibly native to Malaysia, but now widely cultivated in tropical areas and as a greenhouse plant. In Fiji, the root is used as a diuretic. The juice from the bark is taken for thrush and an ulcerated tongue or throat. A poultice made from the bark is used on syphilitic sores. The present study was undertaken to investigate diuretic effect ...

Alismatis rhizoma (AR), the dried rhizoma of Alisma orientale Juzepzuk (Alismataceae), is a traditional Chinese medicine. AR is an important part of many prescriptions and is commonly used as a diuretic agent in Asia. This study aimed to evaluate the diuretic effects of total triterpene extract (TTE) and triterpene component compatibility (TCC, the mixture of alisol B 23-acetate, alisol B, alis...

AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients. METHODS A two-center, randomized, open-label, prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group (received 7.5 mg of tolvaptan) or the conventional diuretic group (received 40 mg of furosem...

PRIOR TO the advent of potent oral diuretics, pareliteral mercurial drugs were the mainstays of diuretic therapy. In the search for orally effective diuretic agents, several events stand out. In 1949, Schwartz1 reported the diuretic effect of sulfanilamide in patients with congestive heart failure. In 1953, acetazolamide, a sulfonamide derivative and a potent carbonic anhydrase inhibitor, becam...

The present study was undertaken to investigate the diuretic effect of ethanolic seed extracts of Macrotyloma uniflorum and Cucumis melo in Albino rats. Ethanolic extracts of the seeds were administered to experimental rats orally at doses of 200mg/kg and 400mg/kg each p.o. Furosemide (5mg/kg) was used as a standard. The diuretic effects of the extracts were evaluated by measuring the Urine vol...

Peripheral oedema is a commonly encountered clinical problem. Although it has many causes, its pathophysiology ultimately involves two processes: altered capillary haemodynamics and renal salt and water retention. A minority of cases are resistant to diuretic treatment; causes of such resistance include excessive sodium intake, poor diuretic drug absorption, reduced secretion of free diuretic i...