Purpose: To evaluate the diuretic effect of the aqueous methanol extract of Mentha viridis Linn (Labiatae) in Albino rats. Methods: The aqueous-methanol extract of Mentha viridis was administered to experimental rats at doses of 30, 50 and 100 mg/kg, (i.p.) Furosemide 10 mg/kg (i.p.) and normal saline were used as reference drug and control, respectively. Diuretic effect was examined immediatel...

To study the diuretic effects of cleistanthin A and cleistanthin B, phytoconstituents were isolated from the leaves of Cleistanthus collinus in Wistar rats. The in vivo diuretic effects of cleistanthins A and B were determined according to the Lipschitz test. Prior to the experiment, the animals were fasted for 5 h and placed individually in metabolic cages. Cleistanthins A and B (12.5, 25, and...

The purpose of this study was to assess the effects of the calcium entry blocker nicardipine and alpha human atrial natriuretic peptide (hANP) on antihypertensive and diuretic activity in hypertensive surgical patients. The site of the diuretic actions of these drugs along the nephron were also investigated by measuring the excretion rate of inorganic phosphate (PO4). Hypertension during gastre...

  The common use of maternal ultrasonography has increased the apparent incidence of neonatal hydronephrosis. Many of these cases are found to have partial obstruction at the ureteropelvic junction (UPJ). These patients are safely managed in our institution with careful observation and only occasionally require surgical intervention. The authors present two contrastin...

AIMS We studied the characteristics and clinical outcome related to diuretic response and the effects of serelaxin in patients hospitalized for acute heart failure (AHF). METHODS AND RESULTS RELAX-AHF was a double-blind, placebo-controlled trial, enrolling 1161 patients admitted to hospital for AHF who were randomized to 48 h i.v infusions of placebo or serelaxin (30 µg/kg per day) within 16 ...

OBJECTIVES The aim of this study was to characterize the association between decongestion therapy and 30-day outcomes in patients hospitalized for heart failure (HF). BACKGROUND Loop diuretic agents are commonly prescribed for the treatment of symptomatic congestion in patients hospitalized for HF, but the association between loop diuretic agent dose response and post-discharge outcomes has n...

Consider an experiment in which 10 subjects receive a placebo, and another 10 receive an experimental diuretic. After 8 h, the average urine output in the placebo group is 769 mL, versus 814 mL in the diuretic group—a difference of 45 mL (Figure 1). How do we know if that difference means the drug works and is not just a result of chance? of 45 mL in the average urine output between groups unde...

UNLABELLED Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. METHODS We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging result...

Moringa stenopetala (Baker f.) Cufod. is a medicinal plant that has been used for the treatment of different ailments such as hypertension and diabetes in Ethiopia. This study aims to assess the diuretic activity of the aqueous crude extract and hot tea infusion of M. stenopetala leaves in saline-loaded rats. Male Wistar rats were divided into ten groups (n = 5). The control group received dist...