نتایج جستجو برای: distal clearance margin dcm

تعداد نتایج: 153700  

Journal: :Journal of Heart and Lung Transplantation 2022

IntroductionBecker muscular dystrophy (BMD) is an X-linked recessive disorder with dystrophin mutation. Dilated Cardiomyopathy (DCM) a leading cause of death in BMD patients. Herein, we are presenting patient that initially sought medical attention for acute onset systolic heart failure highlights the importance careful clinical assessment and appropriate work up.Case ReportA 29-year-old male h...

2013
Masami Sugihara Fuminori Odagiri Takeshi Suzuki Takashi Murayama Yuji Nakazato Kana Unuma Ken-ichi Yoshida Hiroyuki Daida Takashi Sakurai Sachio Morimoto Nagomi Kurebayashi

BACKGROUND Inherited dilated cardiomyopathy (DCM) is a progressive disease that often results in death from congestive heart failure (CHF) or sudden cardiac death (SCD). Mouse models with human DCM mutation are useful to investigate the developmental mechanisms of CHF and SCD, but knowledge of the severity of CHF in live mice is necessary. We aimed to diagnose CHF in live DCM model mice by meas...

Journal: :Molecular medicine reports 2015
Guiying Chen Xu Wang Yina Zhang Xiaoxue Ru Lijun Zhou Ye Tian

Dilated cardiomyopathy (DCM) is one of the leading causes of mortality; however, the underlying molecular mechanisms of DCM remain to be elucidated. H3K9 histone methyltransferase G9a has been previously characterized, although its functions in DCM are not yet understood. Cell adhesion molecules (CAM) are highly expressed in diseased human hearts and were thought to contribute to chronic degene...

Journal: :International journal of molecular medicine 2015
Xian-Ling Zhang Neng Dai Kai Tang Yan-Qing Chen Wei Chen Juan Wang Cui-Mei Zhao Fang Yuan Xing-Biao Qiu Xin-Kai Qu Yi-Qing Yang Ya-Wei Xu

Dilated cardiomyopathy (DCM), the most common form of primary myocardial disease, is an important cause of sudden cardiac death and heart failure and is the leading indication for heart transplantation in children and adults worldwide. Recent studies have revealed a strong genetic basis for idiopathic DCM, with many distinct genes causally implicated. Nevertheless, DCM is a genetically heteroge...

Journal: :Circulation 2005
John L Jefferies Benjamin W Eidem John W Belmont William J Craigen Stephanie M Ware Susan D Fernbach Steven R Neish E O'brian Smith Jeffrey A Towbin

BACKGROUND Dystrophin gene mutations cause 2 common muscular dystrophies, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Both are frequently associated with dilated cardiomyopathy (DCM) and premature death. We hypothesized that early diagnosis and treatment of DCM in DMD/BMD patients would lead to ventricular remodeling and that specific dystrophin gene mutations would p...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
N R Janjua T E Jonassen S Langhoff K Thomsen S Christensen

The mechanisms underlying the acute antidiuretic response to bendroflumethiazide (BFTZ; 0.25 mg/h for 3 h) in rats with nephrogenic diabetes insipidus (NDI) was investigated. NDI was induced in conscious chronically instrumented female Wistar rats either by chronic lithium administration (40-60 mmol Li/kg of diet for 4 weeks) or by acute infusion of V2 antagonist OPC-31260 (0.2 mg/h). Renal cle...

2017
Chia-Ming Chang Wen-Tien Wu Kuan-Lin Liu Kuang-Ting Yeh Cheng-Huan Peng Ing-Ho Chen

OBJECTIVE Despite its possible role in knee arthroplasty, the proximal-distal condylar length (PDCL) of the femur has never been reported in the literature. We conducted an anatomic study of the proximal aspect of the medial femoral condyle to propose a method for measuring the PDCL. MATERIALS AND METHODS Inspection of dried bone specimens was carried out to assure the most proximal condylar ...

Journal: :The Journal of clinical dentistry 1992
K N Rustogi J P Curtis A R Volpe J H Kemp J J McCool L R Korn

To improve the assessment of plaque present on teeth, a new index, based on the original Modified Navy Plaque Index, has been developed. The primary modifications to the original Modified Navy Plaque Index were: (1) extending areas F (distal) and D (mesial) into the region just below the interproximal contact point, and (2) extending areas C and A so as to increase the gumline (or marginal ging...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
P Solter D Sisson W Thomas L Goetze

Neutral endopeptidase 24.11 (NEP) inhibitors are known to have vascular, diuretic, and natriuretic effects that may be helpful in the treatment of congestive heart failure (CHF). Most NEP inhibitors may act principally through intrarenal mechanisms, which are not completely understood. The purpose of this study was to determine the principal renal effects of the NEP inhibitor ecadotril in dogs ...

Journal: :Heart 1996
U Gabler A Berndt H Kosmehl U Mandel L Zardi S Müller A Stelzner D Katenkamp

OBJECTIVES To investigate whether disturbance of the cellular homoeostasis and integrity of cardiomyocytes in dilated cardiomyopathy (DCM) is accompanied by alterations in cell-matrix relations as indicated by changes in the deposition of fibronectin (FN) isoforms. DESIGN Tissue from a case series of patients with DCM was investigated by immunohistochemistry with antibodies against FN (all va...

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