Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency ...

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes...

Ethylenediamine tetraacetate (EDTA)-mediated calcite dissolution occurs via a different process than water-promoted dissolution. Near-atomic-scale observations in EDTA solutions demonstrate that, after penetration through a critical pit depth barrier, step velocity increases linearly with pit depth for EDTA-promoted dissolution. The parallel processes of water-dominated dissolution at point def...

1. It is possible to fractionate gelatin by means of reprecipitation at 23 degrees C. of a salt-free solution of pH 4.7 into two fractions, one of which is soluble in water at any temperature, and a second one which does not dissolve in water even when heated to 80 degrees C. 2. The proportion of the soluble fraction in gelatin is much greater than of the insoluble one. 3. The insoluble fractio...

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...

The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...

Irbesartan, a widely prescribed anti hypertensive drug belongs to class II under BCS classification and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It needs enhancement in the dissolution rate in its formulation development. Complexation with β-cyclodextrin (βCD) and use of Crospovidone and PVP K 30 are tried for enhancing the dissolution rate of irbesartan...

the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

The dissolution kinetics of pandermite and hydroboracite, present in an Iranian borate ore, in sulfuric acid has been comparatively studied. The effect of particle size, temperature, and acid concentration on their dissolution rate was investigated. Dissolution rates of both minerals increased by reducing the particle size and by raising the temperature. Although, an increase in the acid concen...