be associated with porokeratosis,[8] this diagnosis was not considered owing to the lack of typical clinical features and histology of this condition. Authentic clinical and histologic features of Nekam’s disease are, respectively,[9] a facial seborrheic dermatitislike eruption with tiny confluent papules on the trunk and extremities in linear and reticulate arrays and an infundibulocentric and...

Actinic lichen planus is a clinical variant of lichen planus, involving mainly sun-exposed areas and manifested as annular lesions with a pigmented center surrounded by a hypopigmented zone. A rare presentation of actinic lichen planus mimics melasma but have distinctive histopathologic picture in favour of actinic lichen planus. Herein, we report a 14-year-old boy who presented with a me...

Recent progress in medical sciences and therapy resulted in an increased number of immunocompromised individuals. Candida albicans is the leading opportunistic fungal pathogen causing infections in humans, ranging from superficial mucosal lesions to disseminated or bloodstream candidiasis. Superficial candidiasis not always presents a risk to the life of the infected host, however it significan...

Imiquimod 5% cream (Aldara, 3M Pharmaceuticals) is a topical immunomodulator approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinoma, although it is also used off-label in clinical practice for other dermatologic conditions. Although local side effects are most frequent, it can also produce systemic side effects. We describe the case of a patient who...

Methyl aminolevulinate-hydrochloride cream (Metvix [in Canada] and Metvixia [in the US], Galderma) in combination with photodynamic therapy (PDT) provides an effective treatment option for actinic keratoses (AKs), superficial basal cell carcinoma (sBCC), and Bowen's disease (BD). Good clinical outcomes have been reported in the literature. Complete responses (CRs) in AK range from 69% to 93% at...

INTRODUCTION Trichosporon species are basidiomycetous yeastlike anamorphic organisms that are widely distributed in nature and found predominantly in tropical and temperate areas. In humans, this fungal species is occasionally part of the commensal flora of skin and mucosa, and can be responsible for superficial skin and hair infections (white piedra) or, more rarely, invasive infections in imm...

Porokeratosis is a specific keratinization disorder that manifests clinically as well-demarcated annular or linear keratotic plaques of various sizes and forms and with distinguished histology showing cornoid lamella, which is a column of closely packed parakeratotic cells extending through the stratum corneum. Nail changes secondary to porokeratotic lesions involving digits are quite uncommon ...