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The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe skin ulcers (cutaneous leishmaniasis [CL]), limited or disseminated lesions, or lethal visceral disease. We previously reported an association between IL-2R mutations and susceptibility to visceral leishmaniasis in children infected with...

The effects in vivo of the bisphosphonate drug pamidronate, used in bone resorption therapy, were investigated in an experimental model of cutaneous leishmaniasis. Pamidronate at an intraperitoneal dose of 10 mg/kg/day for 5 days effects a radical cure of cutaneous leishmaniasis in Balb/c mice, as evidenced by long-term disappearance of lesions; disappearance of amastigotes in lesion sites, as ...

American cutaneous leishmaniasis is in full geographic expansion in Brazil and it is considered among the infectious and parasitic diseases of utmost importance worldwide, not only by its frequency, but mainly by therapeutic difficulties, deformities and sequelae that may result. In the state of Rio de Janeiro, the first autochthonous case of American cutaneous leishmaniasis was registered by R...

We report an imported case of cutaneous leishmaniasis in a 37-year-old man from Saudi Arabia caused by Leishmania major. He presented with non-healing nodulo-ulcerative lesions with a "volcanic crater" on the lower limbs. It was clearly cutaneous leishmaniasis - a rare disease in China - as reflected by the patient's clinical history, the lesions' morphology, histopathological examination, cult...

conclusions l. major is the main species responsible for cutaneous leishmsniasis in four geographical regions of khuzestan province southwestern of iran and nested pcr can be used for diagnosis and leishmania species identification. results 138 (94.5%) out of 146 cases of four regions were l. major and 8(5.5%) were l. tropica. 57.97% of l. major cases were male and 42.03% were female. 87.5% of ...

background : cutaneous leishmaniasis is one of the prevalent health problems in tropical and subtropical areas including iran. therefore, it is essential to identify the prevalence and new foci of this disease in different regions of iran. this study aimed to determine the epidemiology of cutaneous leishmaniasis by active surveillance in elementary schools in pakdasht city, southeast of tehran,...

cutaneous leishmaniasis (cl) is an endemic disease in iran that is caused by leishmania parasite and transmits to human by phelebotumus sand flies. the lysis of the skin cells occurs by the parasite with the presentation of a dry sore in the rural areas and a wet sore in the urban areas. in this study, the frequency and epidemiologic parameters of cutaneous leishmaniasis patients were studied i...

Although New World cutaneous leishmaniasis is not itself a life-threatening disease, its treatment with systemic antimonials can cause toxicity that can be dangerous to some patients. Intralesional meglumine antimoniate provides a viable, less toxic alternative. Herein, we describe an alternative treatment with subcutaneous intralesional injections of meglumine antimoniate into large periarticu...

Leishmaniasis is caused by Leishmania protozoa. It is widely present in more than 88 countries worldwide, resulting in up to 80,000 deaths annually. Leishmaniasis occurs as visceral, cutaneous, or mucocutaneous variants. Mucosal involvement can occur secondarily to the cutaneous or visceral varieties. However, primary mucosal leishmaniasis (PML) occurs without any present or past cutaneous and ...