Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...

The authors' personal-relational equilibrium model suggests that people come to seek equilibrium in their dedication to personal and relational concerns in that these 2 important needs cannot always be gratified simultaneously. The authors proposed that the experience of personal-relational disequilibrium motivates attempts to restore equilibrium and that achieving equilibrium promotes life sat...

We present a Bayesian method that combines linkage and linkage disequilibrium (LDL) information for quantitative trait locus (QTL) mapping. This method uses jointly all marker information (haplotypes) and all available pedigree information; i.e., it is not restricted to any specific experimental design and it is not required that phases are known. Infinitesimal genetic effects or environmental ...

pre-implant disease is an inflammatory process that affects the surrounding tissues of a functional osseointegrated implant. it is usually the result of a disequilibrium between the micro-flora and the defense system. this case reports a 57-year-old man with unusual bone loss around dental implants. this was an unusual case of peri-implantitis that occurred only in the implants on one side of t...

genetic diversity of red jabal barez red goat population was studied based on eight microsatellite markers consist bm1312, maf64, ilsts034, ilsts059, orafcb20, il2ra, lscv24 and lscv11. blood sample extracted of 100 red jabal barez goats were randomly collected from 10 farms and dna was isolated using the diatom dna prep kit. the pcr reactions were successfully done and all loci showed suitable...

The theory of monetary disequilibrium, as espoused by Selgin (1988), White (1989), Horwitz (2000), and others, has been used to justify the issuance of fiduciary media under a system of fractional reserve “free” banking. The present paper examines this monetary disequilibrium theory and concludes that it contains numerous errors and logical fallacies. The foundational economic argument in favor...

Measurement of linkage disequilibrium involves two sampling processes. First, there is the sampling of gametes in the population to form successive generations, and this generates disequilibrium dependent on the effective population size ( N , ) and the mating structure. Second, there is sampling of a finite number ( n ) of individuals to estimate the population disequilibrium. ---Two-locus des...

Linkage mapping generally localizes disease genes to 1- to 2-cM regions of chromosomes. In theory, further refinement of location can be achieved by population-based studies of linkage disequilibrium between disease locus alleles and alleles at adjacent markers. One approach to localization, dubbed simple disequilibrium mapping, is to determine the relative location of the disease locus by plot...

Description R package for design of experiments for association studies for detection of linkage disequilibrium. Uses an existing deterministic power calculation for detection of linkage disequilibrium between a bi-allelic QTL and a bi-allelic marker, together with the Spiegelhalter and Smith Bayes factor to generate designs with power to detect effects with a given Bayes factor.

Haplotypes Linkage equilibrium and disequilibrium Additive, multiplicative, epistatic tness regimes Causes of linkage disequilibrium Extent of disequilibrium in nature Multilocus population genetics is the study of the distribution and dynamics of genetic variation at several loci in biological populations. Haplotypes Even the simplest known biological organisms have thousands of genes and mill...