BACKGROUND Studies have shown that approximately 80% of hypertensive patients do not take diuretics despite their recommendation as a first-line therapy. A recent study reported that hypertensive patients with the Gly460Trp variant in the alpha-adducin gene are more likely to benefit from diuretic therapy. The objective of this study was to evaluate the potential cost effectiveness of screening...

BACKGROUND Understanding the progression from beryllium exposure (BeE) to chronic beryllium disease (CBD) is essential for optimizing screening and early intervention to prevent CBD. METHODS We developed an analytic markov model of progression to cbd that assigns annual probabilities for progression through three states: from BeE to beryllium sensitization and then to CBD. We used calculation...

The cost-effectiveness of treatment for hypertension is positively related to the level of pretreatment blood pressure and to the level of success in achieving patient adherence to prescribed medical regimens. Opportunities to improve the cost-effectiveness of treatment include limiting treatment to patients with well-documented sustained increases in blood pressure, giving higher priority to t...

The efficacy and relative cost-effectiveness of insecticide-treated nets (ITNs) for the control of malaria in children under 5 years of age have recently been demonstrated by several large-scale trials. However, it has been suggested that long-term use of ITNs in areas of high transmission could lead to mortality rebound in later childhood, which would reduce the cost-effectiveness of the inter...

List of abbreviations Executive summary Background Objectives Methods Results Conclusions Recommendations for research Funding Chapter 1 Background Lysosomal storage disorders Summary of lysosomal storage disorders investigated in this study Patterns of treatment in England Rationale for the cohort study Background and objectives Chapter 2 Methods Study procedures Data collection Methods used i...

In this paper we quantify the total cost of an epidemic spreading through a social network, accounting for both the immunization and disease costs. Previous research has typically focused on determining the optimal strategy to limit the lifetime of a disease, without considering the cost of such strategies. In the large graph limit, we calculate the exact expected disease cost for a general ran...

Sischo, W.M., Hird, D.W., Gardner, I.A., Utterback, W.W., Christiansen, K.H., Carpenter, T.E., Danaye-Elmi, C. and Heron, B.R., 1990. Economics of disease occurrence and prevention on California dairy farms: a report and evaluation of data collected for the National Animal Health Monitoring System, 1986-1987. Prey. Vet. Med., 8: 141-156. A stratified random sample of 43 dairy herds in Californi...

Studies on burden of disease and cost of illness investigate life loss and economic loss caused by a disease. 1 They determine the degree of economic loss following a disease, to establish governmental policies and to identify research topics in a new area. Comparison the studies among the cost of illness, burden of disease, and economic evaluation clarifies their characteristics. They use simi...