Accessible online at: www.karger.com/drm The article by Sonntag et al. [1] in this issue of Dermatology describes 3 children with lupus erythematosus (LE) tumidus, a rare subtype of cutaneous LE which has previously not been reported in this age group. Discoid LE (DLE) is very uncommon in childhood: less than 2% of all patients with DLE have onset of the disease before the age of 10 years [2]. ...

Sir, Ultraviolet radiation (UVR) induces isomerization of transurocanic acid (UCA), a natural component of human skin, into cis-UCA, which has been shown to suppress both delayed hypersensitivity and contact hypersensitivity (1). An autoantigen-speci®c T-cell-mediated mechanism has been proposed in both chronic cutaneous lupus erythematosus, presenting mostly as discoid lupus erythematosus (DLE...

One of the most difficult problems in medicine is the correct estimation of the value of any new method of treatment which is not absolutely specific. Not only is enthusiasm liable to run riot at the incidence of a series of successful cases, but the reverse may also occur, and undue depreciation of the value of a useful method be engendered by an initial series of tmsuccessful cases.

Previous research suggested that 16-week old dog pups, but not wolf pups, show attachment behaviour to a human caregiver. Attachment to a caregiver in dog pups has been demonstrated by differential responding to a caregiver compared to a stranger in the Ainsworth Strange Situation Test. We show here that 3-7 week old wolf pups also show attachment-like behaviour to a human caregiver as measured...