نتایج جستجو برای: disc1 gene
تعداد نتایج: 1141646 فیلتر نتایج به سال:
Schizophrenia is a complex mental disorder with a fairly high degree of heritability. Although the causes of schizophrenia remain unclear, it is now widely accepted that it is a neurodevelopmental and neurodegenerative disorder involving disconnectivity and disorder of the synapses. Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene involved in neurodevelopment, i...
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute disease later life. We investigated whether a lifestyle intervention pregnant women with is associated variation cord blood body composition offspring. Genome-wide DNA methylation was analyzed from 208 Treatment of Obese Pregnant (TOP)-study, which includes randomized interventions comprised physic...
Background: Disrupted proteostasis is an emerging area of research into major depressive disorder. Several proteins have been implicated as forming aggregates specifically in the brains subsets patients with psychiatric illnesses. These include CRMP1, DISC1, NPAS3 and TRIOBP-1. It unclear, however, whether these normally aggregate together same individuals and, if so, each protein independently...
Carefully designed animal models of genetic risk factors are likely to aid our understanding of the pathogenesis of schizophrenia. Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects of a schizophrenia-predisposing mutation and offer a detailed account of the consequences that this mutation has on the development and function of ...
With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia affects the most basic human processes of perception, emotion, and judgment. Evidence increasingly suggests that schizophrenia is a subtle disorder of brain development and plasticity. Genetic studies are beginning to identify proteins of candidate genetic risk factors for schizophrenia, including dysbin...
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