Abstract Eurasians have ~2% Neanderthal ancestry, but we lack a comprehensive understanding of the genome-wide influence introgression on modern human diseases and traits. Here, quantify contribution introgressed alleles to heritability more than 400 diverse We show that genomic regions in which detectable ancestry remains are depleted for all traits considered, except those related skin hair. ...

Self-assembled synthetic materials are typically disordered, and controlling the alignment of such materials at the nanometer scale may be important for a variety of biological applications. In this study, we have applied directional freeze-drying, for the first time, to develop well aligned three dimensional (3D) nanofibrous materials using amino acid like L-phenylalanine (Phe). 3D free-standi...

Metropolis–Hastings algorithms are used to simulate Markov chains with limiting distribution equal to a specified target distribution. The current paper studies target densities on R. In directional Metropolis–Hastings algorithms each iteration consists of three steps i) generate a line by sampling an auxiliary variable, ii) propose a new state along the line, and iii) accept/reject according t...

We argue that hypotheses for how chromosomes achieve a metaphase alignment, that are based solely on a tug-of-war between poleward pulling forces produced along the length of opposing kinetochore fibers, are no longer tenable for vertebrates. Instead, kinetochores move themselves and their attached chromosomes, poleward and away from the pole, on the ends of relatively stationary but shortening...

Leidenfrost phenomena on nano- and microstructured surfaces are of great importance for increasing control over heat transfer in high power density systems utilizing boiling phenomena. They also provide an elegant means to direct droplet motion in a variety of recently emerging fluidic systems. Here, we report the fabrication and characterization of tilted nanopillar arrays (TNPAs) that exhibit...

Ideal strength, which can be defined as the stress necessary to induce permanent deformation in a material without prior imperfections, is one of the important materials characterizations. In this study we calculate the ideal pure shear and simple shear strengths of fcc (Al, Cu, Ni, Ag) and bcc (Fe, Mo, W) metals in their common slip systems using density functional theory. We find the critical...