Our understanding of the various types and patterns of diffuse lung disease that might result in fibrosis has evolved considerably over the last 50 years. Many entities now regarded as distinct had been previously "lumped'' together as a single disease, "lung fibrosis,'' and more recently misdiagnosed as idiopathic pulmonary fibrosis (IPF, synonymous with cryptogenic fibrosing alveolitis). In 1...

The charge-stabilization method is applied to double ionization potential equation-of-motion (EOM-DIP) calculations to stabilize unstable dianion reference functions. The auto-ionizing character of the dianionic reference states spoils the numeric performance of EOM-DIP limiting applications of this method. We demonstrate that reliable excitation energies can be computed by EOM-DIP using a stab...

Transcription factor E2F plays an important role in orchestrating early cell cycle progression through its ability to co-ordinate and integrate the cell cycle with the transcription apparatus. Physiological E2F arises when members of two distinct families of proteins interact as E2F-DP heterodimers, in which the E2F component mediates transcriptional activation and the physical interaction with...

OBJECTIVE Prospective evaluation of pregnancy outcomes in women with pregestational diabetes over 6 years. RESEARCH DESIGN AND METHODS The ATLANTIC Diabetes in Pregnancy group provides care for women with diabetes throughout pregnancy. In 2007, the group identified that women were poorly prepared for pregnancy and outcomes were suboptimal. A change in practice occurred, offering women special...

We discuss commercial expert system development, using our experience with the Dipmeter Advisor system as a case study. While the data is too sparse for definitive results, several ideas have emerged as important and suggestive as guidelines for subsequent commercial expert system undertakings. During the past four years, the Dipmeter Advisor system has migrated from an initial experiment in ap...

A feeding trial evaluated the hypothesis that wet corn gluten feed would improve growth performance of cattle fed steam-flaked corn-based finishing diets and supply required degradable intake protein (DIP). The trial used 360 steer calves (initial BW = 288 +/- 11 kg) housed in 36 pens for 166 d in an incomplete 4 x 3 factorial arrangement of treatments. Pens of steers were assigned to treatment...

Background In psoriatic arthritis (PsA), nail disease is intimately linked to the presence of DIP joint enthesitis and arthritis. Nail disease has been shown in clinical trials to respond to treatment with TNF inhibitors. We used high resolution MRI to assess whether improvements in psoriasis-related nail disease correlated to improvements in associated DIP joint enthesitis, osteitis and synovi...

Modeling and Simulation of an Emulsion Copolymerization Process Sabrina Copelli*, Mario Dente, Marco Derudi, Giulia Bozzano, Vincenzo Torretta Università degli Studi dell’Insubria Dip. di Scienza e Alta Tecnologia Via G.B. Vico 46 21100 Varese Italy b Politecnico di Milano Dip. di Chimica, Materiali e Ingegneria Chimica “G. Natta”P.za Leonardo da Vinci 20133 Milano Italy sabrina.copelli@uninsub...

PURPOSE To compare circadian changes of systemic circulation in patients with normal tension glaucoma (NTG) and normal subjects. METHODS Forty-three patients with NTG and 226 normal subjects were enrolled in this study. Circulatory parameters, including blood pressure (BP) and pulse rate (PR), were measured in all subjects for 49 hours using an ambulatory monitoring system. In addition to a c...