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A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of Nebivolol hydrochloride and Cilnidipine in tablet dosage form. A Spheri-5-RP-18 column having 250×4.6 mm i.d., with mobile phase composed of Methanol: 20 mM Ammonium acetate (85:15, v/v; pH 4.0 adjusted with Formic acid. The rete...

clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and tourette syndrome. the quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. therefore, the aim of this study was to establish the conditions for two spectroph...

IMPORTANCE Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations. OBJECTIVE To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population. DESIG...

Analgesic effects were conducted with 2% lignocaine hydrochloride (LH), 2% lignocaine hydrochloride with adrenaline (LHA) and 0.5% bupivacaine hydrochloride (BH) in calves of both sexes. Analgesic drugs were injected into caudal epidural space in 30 apparently healthy calves of below one year of age. A total of 30 analgesic trials were done, where heart rate, respiration rate and rectal tempera...

This multicentre, randomised, double-blind, placebo-controlled, parallel-group study investigated the efficacy, safety and pharmacokinetics of remacemide hydrochloride in adult patients ( n= 59) with refractory epilepsy, undergoing reduced or discontinued antiepileptic drug (AED) usage, as part of an evaluation for epilepsy surgery. On discontinuation or reduction of maintenance AEDs, patients ...

The efficacy, safety and pharmacokinetics of adjunctive remacemide hydrochloride, a novel, low-affinity non-competitive NMDA receptor channel blocker, were investigated in 28 adult patients with refractory epilepsy. This was a randomized double-blind placebo-controlled cross-over study with five 4-week periods (baseline, treatment 1, washout, treatment 2, washout). Baseline median seizure frequ...