Dimethyl amino ethyl azide (DMAZ) is a good replacement for hydrazine group in space programs. This chemical was purified from water (1) + DMAZ (2) mixture in sub-atmospheric distillation column due to thermal sensitivity of DMAZ. For designing of the column, it is necessary to have vapor-liquid equilibrium data. In this article, T-x,y and y-x diagrams were obtain...

Ethanol alters the function of several members of the Cys-loop ligand-gated ion channel superfamily. Recent studies have shown that the sensitivity of the α1 glycine receptor (GlyR) to ethanol can be affected by the state of G protein activation mediated by the interaction of Gβγ with intracellular amino acids in the GlyR. Here, we evaluated the physicochemical property of Lys385 that contribut...

We tested the hypothesis that recognized gastroprotective agents exert direct protection against ethanol-induced injury in isolated rat gastric mucosal cells in vitro. If protection exists, we also wanted to identify subcellular targets in the reversible and/or irreversible stages of cell injury. Ethanol-induced cell injury was quantified by measuring plasma membrane leakage (trypan blue exclus...

We prepared corn peptide (CP), a vegetable oligopeptide and tried to discover the effects of its ingestion on facilitating alcohol metabolism in healthy adult men. Ten healthy male volunteers ingested 5 g of CP, wheat peptide (WP), pea peptide (PP), alanine, or leucine 30 min before alcohol intake at a dose of 0.5 g/kg, and blood ethanol and plasma amino acid concentrations were measured during...

Ethanol is a general anesthetic agent as defined by abolition of movement in response to noxious stimulation. This anesthetic endpoint is due to spinal anesthetic actions. This study was designed to test the hypothesis that ethanol acts directly on motor neurons to inhibit excitatory synaptic transmission at glutamate receptors. Whole cell recordings were made in visually identified motor neuro...

In this work, series of new chalcones derived from indole compounds were synthesized. the first compound 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)malonaldehyde was synthesized reaction 1,1,2-trimethyl-1H-benzo[e]indole with Phosphoryl chloride in presence (DMF). Schiff base (C2) prepared by 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde 3-amino acetophenone ...