The non-coding part of our genome contains sequence motifs that can control gene transcription over distance. Here, we discuss functional genomics studies that uncover and characterize these sequences across the mammalian genome. The picture emerging is of a genome being a complex regulatory landscape. We explore the principles that underlie the wiring of regulatory DNA sequences and genes. We ...

One challenge in supramolecular chemistry is the design of versatile, self-assembling building blocks to attain total control of arrangement of matter at a molecular level. We have achieved reliable prediction and design of the three-dimensional structure of artificial RNA building blocks to generate molecular jigsaw puzzle units called tectosquares. They can be programmed with control over the...

In this paper, a new structure for buck-boost Z-source converter based on Z-H topology is proposed. The proposed converter consists of two LC networks similar to the conventional Z-source and Z-H converters. One of the characteristics of the proposed structure is that, without any changing in its’ power circuit, it can be used in different conversions such as dc/dc, dc/ac and ac/ac. This unique...

In low dimensional topology, we have some invariants defined by using solutions of some nonlinear elliptic operators. The invariants could be understood as Euler class or degree in the ordinary cohomology, in infinite dimensional setting. Instead of looking at the solutions, if we can regard some kind of homotopy class of the operator itself as an invariant, then the refined version of the inva...

Topology control in wireless sensor networks is an important issue for scalability and energy efficiency. It is often based on graph reduction performed through the use of Gabriel Graph or Relative Neighborhood Graph. This graph reduction is usually based on geometric values. In this paper we tackle the problem of possible connectivity loss in the reduced graph by applying a battery level based...

Topology control algorithms are used to improve the energy efficiency (or other quality parameters) of wireless sensor networks. In this paper, we report on the application of graph transformation in the domain of wireless sensor networks by proposing a model-driven rapid prototyping approach for the kTC topology control algorithm to enable the fast implementation and the evaluation of its diff...

The design of effective Medium Access Control protocol for ad hoc network is a highly challenging task due to the characteristics of such networks. The medium is shared and unreliable by definition, thus the access mechanism should be robust to channel errors and collisions. Furthermore, all the coordination functions must be totally distributed in a pure ad hoc environment. In this paper we ad...