Circular dichroism spectroscopy (CD) sensitively reflects even slight alterations of the base stacking geometry in DNA (Tinoco et al. 1980; Johnson et al. 1981). However, the alterations cannot be unambiguously interpreted in conforma­ tional terms so that, for example, the question concerning the origin of the relatively extensive temperature-induced changes in the CD spectrum of a synthetic D...

BACKGROUND The degree of anisotropy (DA) on radiographs is related to bone structure, we present a new index to assess DA. METHODS In a region of interest from calcaneus radiographs, we applied a Fast Fourier Transform (FFT). All the FFT spectra involve the horizontal and vertical components corresponding respectively to longitudinal and transversal trabeculae. By visual inspection, we measur...

AbstrAct California sea lion (Zalophus californianus) mortality attributed to the neurotoxin domoic acid (DA) produced by the diatom Pseudo-nitzschia has occurred repeatedly along the United States’ (US) west coast since the late 1990s. The purpose of this study was to provide a comparison of DA concentrations for several method platforms in the analysis of sea lion body fluids and to validate ...

Three monoclonal antibodies (MAbs) against nitrite oxidoreductase (NOR) of Nitrobacter hamburgensis were produced. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting analysis of the purified enzyme showed that the MAbs named Hyb 153.1 and Hyb 153.3 both recognized a protein with a molecular mass of 64,000 Da, while Hyb 153.2 recognized a protein with a molecular mass o...

Data on efficacy and safety of darbepoetin alfa (DA) administered at hemoglobin (Hb) ≤10 g/dL are limited. In this analysis, we examined DA's efficacy and safety in patients with Stage IV cancers and chemotherapy-induced anemia (CIA) initiated on DA at Hb ≤10 g/dL. Data for patients with Stage IV cancers and CIA and who initiated DA at Hb ≤10 g/dL were extracted from three phase 3 trials identi...

The E proteins of mammals, and the related Daughterless (DA) protein of Drosophila, are ubiquitously expressed helix-loop-helix (HLH) transcription factors that play a role in many developmental processes. We report here the characterization of a related C. elegans protein, CeE/DA, which has a dynamic and restricted distribution during development. CeE/DA is present embryonically in neuronal pr...

Discriminant analysis DA is used for the measurement of estimates of a discriminant function by minimizing their group misclassifications to predict group membership of newly sampled data. A major source of misclassification in DA is due to the overlapping of groups. The uncertainty in the input variables and model parameters needs to be properly characterized in decision making. This study com...