In a prospective long-term follow-up of 84 patients 21 years after first hospitalisation for anorexia nervosa, we found that 50.6% had achieved a full recovery, 10.4% still met full diagnostic criteria for anorexia nervosa, and 15.6% had died from causes related to anorexia nervosa. Predictors of outcome included physical, social, and psychological variables.

BACKGROUND Among psychiatric disorders, anorexia nervosa has the highest mortality rate. During an exacerbation of this illness, patients frequently present with nonspecific symptoms. Upon hospitalization, anorexia nervosa patients are often markedly bradycardic, which may be an adaptive response to progressive weight loss and negative energy balance. When anorexia nervosa patients manifest tac...

The behavioural literature in anorexia nervosa and autism spectrum disorders has indicated an overlap in cognitive profiles. One such domain is the enhancement of local processing over global processing. While functional imaging studies of autism spectrum disorder have revealed differential neural patterns compared to controls in response to tests of local versus global processing, no studies h...

The association between pregnancy and perinatal complications (PPCs) and risks for adult psychiatric disorders other than psychoses has received relatively limited attention. In this study, we aim to characterize the associations between PPCs and risks for anxiety, affective, substance use, and eating disorders in a population-based sample of twins. Personal interviews were conducted with 1,806...

The clinical manifestations of zinc deficiency and anorexia nervosa are remarkably similar, and a number of studies have demonstrated that there may be a positive correlation between zinc therapy and the rate of recovery of anorexia nervosa patients. However, because of the different interpretations of the results of these studies, the use of zinc supplementation varies. This article examines t...

BACKGROUND Previous research in patients with anorexia nervosa showed heightened brain response during a taste reward conditioning task and heightened sensitivity to rewarding and punishing stimuli. Here we tested the hypothesis that individuals recovered from anorexia nervosa would also experience greater brain activation during this task as well as higher sensitivity to salient stimuli than c...

a serum phosphorus if ATPase enzyme is available. Maintenance plasma levels range between 10 and 40 m,ug/ml with a mean value of 25 mrjug/ml. There is overlapping of maintenance and toxic serum levels in the higher ranges. Values over 45 m,ug/ml warrant careful evaluation for digitalis intoxication. Maintenance plasma levels can be achieved with or without the usual digitalizing dosage if time ...

For many years it has been suggested that considerable quantities of digitalis bodies accumulate in edema fluid, that rapid diuresis with mercurial diuretic drugs "liberates" these glycosides into the blood stream as the edema fluids are mobilized and excreted by the kidneys, and that the ensuing "redigitalization" may lead to manifestations of digitalis toxicity in the already adequately digit...

When Policy Topic is covered A number of indications for chelation therapy have received Food and Drug Administration (FDA) approval and for which chelation therapy is considered standard of care treatment. They include:  extreme conditions of metal toxicity;  treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) and due to non-transfusion-dependent thalas...

Electrode catheter recordings of the bundle of His (H), the right bundle branch (RB) and the left bundle branch (LB) were obtained in 15 dogs without thoracotomy during sinus rhythm and digitalis-induced ventricular tachycardia. During sinus rhythm an H-RB-LB sequence was recorded. This sequence was unchanged during atrial stimulation at rapid rates or during cardiac slowing by vagal stimulatio...