The involvement of estrogen and its receptors in the development of cancer has been known for years. However, the exact mechanism responsible is far from clear. The estrogen-mediated carcinogenic process is complicated by recent findings, which reveal that estrogens have multiple functions in cells, which can be either adverse or beneficial, and that the effects of estrogen may be cell-type or ...

We examined AIS status in digestive tract cancers and found that all eight esophageal cancer cell lines (100%) showed AIS/TA-AIS gene overexpression, whereas 1 of 12 (8%) gastric cancer and 0 of 14 (0%) colon cancer cell lines showed AIS/TA-AIS gene expression. We then confirmed that the AIS gene, not the TA-AIS gene, was dominantly expressed in esophageal cancers by reverse transcriptionPCR. A...

BACKGROUND Periodic concerns about excesses of cancer among teachers in California schools prompted our examination of cancer incidence in California school employees. METHODS Records of school employees between 1987-1992 were linked to the California Cancer Registry of incident cases diagnosed 1988-1992. Sex-, race-, and age-adjusted standardized incidence ratios were calculated for specific...

Cancer morbidity at all sites has been studied in a series of 676 patients with ulcerative colitis under long-term review, of whom more than two-thirds had extensive disease, and the level and pattern of risk over time examined. Age-, sex-, and site-specific incidence rates were used to compute the number of cancers that might have been expected to occur. A highly significant excess of cancers ...

BACKGROUND AND AIMS Little is known about the epidemiology of rare epithelial digestive cancers. The aim of this study was to report on their incidence, prevalence and survival across Europe. METHODS The analysis was carried out on 50,646 cases diagnosed from 1995 to 2002 within a population of 162,000,000 in 21 European countries. Age-standardised incidence rates were computed using the Euro...

Background: Radium-226 (226Ra) is a product of the 238U radionuclide decay series that significantly incorporated into the human body through water intake. It can also potentially cause a series of health problems including cancers of the digestive system. Radium-226 (226Ra) is a product of the 238U radionuclide decay series that significantly incorporated into the human body through water ...

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder equally affecting males and females with an incidence of 1/25,000 – 1/300,000 births. It characterised by the development hamartomatous polyps digestive tract, lifetime risk colorectal cancer other gastrointestinal malignancies, as well non-gastrointestinal cancers such breast ovarian cancers. Intestinal polyposis very common in...

Among 232 cases of operable breast cancer treated by the 2nd Department of Surgery, Hiroshima University School of Medicine, between 1963 and 1982, 7 cases (3. 0%) were followed by a second primary malignancy. Eighty six percent of the second primary malignancies were found in digestive systems. The incidence of a second primary malignancy was 6. 1%* (5/82) in the irradiated group and 1. 3%* (2...