address correspondence to: María Victoria García-Pallas, MD, 50 Calle San José, Apt. 502, Guaynabo PR 00969. Tel: (787) 708-2784 • Fax: (787) 708-9884 Diffuse large-cell lymphoma (DLCL) is one of the most chemotherapy curable neoplasm. even in patients who present with metastatic disease, an appreciable and increasing percentage can be cured. However, not all patients are cured. furthermore, th...

1 of 2 DESCRIPTION A 47-year-old gentleman was diagnosed with diffuse B cell lymphoma. His initial presentation was skin lesions. He was then referred for patch test with a diagnosis of periorbital eczema. Later, patient developed varicose veins and skin lesions in the right leg which was operated upon with poor healing and subsequent skin biopsy of the lesions demonstrated diffuse large B cell...

Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of ab...

Substantial additional insight has been obtained in the past decade regarding the pathogenesis of diffuse large B cell lymphoma (DLBCL). Distinct subtypes of DLBCL have been defined by gene expression profiling (GEP) and they differ not only in GE profiles but also in the pattern of genetic abnormalities. The ability to correlate corresponding genetic and GEP data markedly facilitates the ident...

Clonal heterogeneity in lymphoid malignancies has been recently reported in adult T-cell lymphoma/leukemia, peripheral T-cell lymphoma, not otherwise specified, and mantle cell lymphoma. Our analysis was extended to other types of lymphoma including marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma. To determine the presence of clonal heterogeneity, 332 cases were ex...

Diffuse large B-Cell lymphoma is the most common subtype of non-Hodgkin lymphoma in the West. In Brazil, it is the fifth cause of cancer, with more than 55,000 cases and 26,000 deaths per year. At Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP, diffuse large B-Cell lymphoma represents 49.7% of all non-Hodgkin lymphoma cases. Initially, the classification o...