KERATITIS is the chief ocular complication of xeroderma pigmentosum. The severe photophobia, a marked feature of this disease, and the extensive corneal involvement, mainly in the interpalpebral zone, make sufferers from this malady virtually blind, at any rate by day. In a report of seven cases of this disease with ocular complications (Sivasubramaniam and Hoole, 1952), keratoplasty was sugges...

PURPOSE To determine the safety and efficacy of wavefront-guided LASIK for the correction of low to moderate myopia, as performed by surgeons employed by Optical Express, a large corporate provider. METHODS Data were extracted from the Optical Express central database on 22,900 patients (42,143 eyes) who underwent primary LASIK to treat low to moderate myopia and/or astigmatism. All treatment...

By simultaneous coherent anti-Stokes Raman scattering (CARS) and 2-photon fluorescence microscopy of Thioflavin-S stained Alzheimer´s diseased human brain tissues, we show evidence of lipid deposits co-localizing with fibrillar β-amyloid (Aβ) plaques. Two lipid morphologies can be observed; lamellar structures and coalescing macro-aggregates of sub-micron sizes to ~25 μm. No significant lipid d...

OBJECTIVE To evaluate the efficacy and safety of phototherapeutic keratectomy (PTK) in the treatment of symptomatic anterior basement membrane dystrophy following laser in situ keratomileusis (LASIK). METHODS In a retrospective study, 10 eyes of 10 patients that developed symptomatic anterior basement membrane dystrophy following LASIK for myopia were treated with PTK using the VISX S2 (VISX ...

PURPOSE The purpose of this article is to report a case of central toxic keratopathy in a patient post transepithelial photorefractive keratectomy (TransPRK), followed immediately by corneal collagen cross-linking. METHODS This article describes the case of a 26-year-old male after bilateral aberration-free, TransPRK laser (Schwind Amaris 750S). The procedure was performed for compound myopic...

FEBRUARY 2010 CATARACT & REFRACTIVE SURGERY TODAY 49 MARK E. JOHNSTON, MD, FRCSC The three primary concerns with any microkeratome are safety, results, and cost. My colleagues and I have used the IntraLase FS laser (Abbott Medical Optics Inc., Santa Ana, CA) in more than 1,000 cases and the Zyoptix XP microkeratome (Technolas Perfect Vision, Saint Louis, MO) in over 10,000 cases. Both procedure...

Protein arginine methyl transferase 5 (Prmt5) regulates various differentiation processes, including adipogenesis. Here, we investigated adipogenic conversion in cells and mice in which Copr5, a Prmt5- and histone-binding protein, was genetically invalidated. Compared to control littermates, the retroperitoneal white adipose tissue (WAT) of Copr5 KO mice was slightly but significantly reduced b...

Cilia are sensory organelles present on almost all vertebrate cells. Cilium length is constant, but varies between cell types, indicating that cilium length is regulated. How this is achieved is unclear, but protein transport in cilia (intraflagellar transport, IFT) plays an important role. Several studies indicate that cilium length and function can be modulated by environmental cues. As a mod...