Objective(s): β-thalassemia is one of the most common genetic disorders in the world. As one of the promising treatment strategies, fetal hemoglobin (Hb F) can be induced. The present study was an attempt to reactivate the γ-globin gene by introducing a gene construct containing KLF1 binding sites to the K562 cell line. Materials and Methods: A plasmid containing a 192 bp sequence with two repe...

       The cellular therapy and nerve tissue engineering will probably become a major therapeutic strategy for promoting axonal growth through injured area in central nervous system and peripheral nervous system in the coming years. The stem cell carrier scaffolds in nerve tissue engineering resulted in strong survival of cells and suitable differentiation into n...

An important recent finding is that testing improves learning and memory. In this article, the authors describe a demonstration that illustrates this principle and helps students incorporate more testing into their learning. The authors asked students to read one text using a Study–Study strategy and one text using a Study–Test strategy. One week later, the authors tested students’ memory for b...

De Vrijer has presented a proof of the finite developments theorem which, in addition to showing that all developments are finite, gives an effective reduction strategy computing longest developments as well as a simple formula computing their length. We show that by applying a rather simple and intuitive principle of duality to de Vrijer’s approach one arrives at a proof that some developments...

3 Adapting the Covariance Matrix 10 3.1 Estimating the Covariance Matrix From Scratch . . . . . . . . . . . . . . . . 10 3.2 Rank-μ-Update . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.3 Rank-One-Update . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 3.3.1 A Different Viewpoint . . . . . . . . . . . . . . . . . . . . . . . . . 14 3.3.2 Cumulation: Uti...

background: diabetes mellitus (dm), simply known as diabetes, refers to a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. in this study, the feasibility and safety of intravenous transplantation of very small embryonic like stem cells (vsels) were investigated for diabetes repair, and finally the migration and distribution of these cells in hosts ...

Objective(s): Three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering due to similarity of their nanofibrous architecture to native extracellular matrix. Co-culture system has stimulatory effect on chondrogenesis of adult mesenchymal stem cells. This work presents a co-culture strategy using human articular chondrons and adipose-derived stem cells (A...

Fitts' (1954) classic theorem asserts that the movement time (MT) of voluntary reaches is determined by amplitude and width requirements (i.e., index of difficulty: ID). Actions associated with equivalent IDs should elicit equivalent MTs regardless of the amplitude and/ or width requirements. However, contemporary research has reported that amplitude-based contributions to IDs yield larger incr...