abstract background: autosomal dominant polycystic kidney disease (adpkd) is an inherited disorder with genetic heterogeneity. up to three loci are involved in this disease, pkdi on chromosome 16p13.3, pkd2 on 4q21, and a third locus of unknown location. methods: here we report the first molecular genetic study of adpkd and the existence oflocus heterogeneity for adpkd in the iranian population...

conclusions while bdg assay seems to be a sensitive and specific adjunctive tool to diagnose and monitor the experimental systemic candidiasis, it seems that measuring the positive cutoff value in different laboratory conditions is necessary for favorable establishment of these tests. results all the infected rats were positive with bdg tests. an increasing level of bdg was observed during earl...

with significant improve in health-care and treatment of infectious diseases, genetic disorders have created a new era of notification. changes in social attitude towards family life and tendency of parents for limited number of children, sense of responsibility of parents for mental and physical healthiness of children along with their education, needed a new strategy. since most genetic disor...

the importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. by taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. they have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. micrornas (mirnas) are o...

constrictive pericarditis (cp) is an uncommon post inflammatory disorder. it is described as pericardial thickening, myocardial constriction, and impaired diastolic filling. the most common etiologies are idiopathy, mediastinal radiotherapy, and prior cardiac surgery. less common etiologies include viral infections, collagen vascular disorders, renal failure, sarcoidosis, tuberculosis, and blun...

background : brucellosis is a major bacterial zoonosis of global importance with the causative organisms of gram-negative facultative intracellular pathogens. the aims of this study were to standardize two immunoelectrophoretic techniques, rocket and cross immunoelectrophoresis, and compare their results with other conventional serodiagnostic tests. methods : sera from 15 sheep, without any his...

oral cancer has emerged as a significant cause of global public health concern in both developing and developed nations. multiple socio-demographic and habit-related risk factors have been attributed to causing oral cancer. a diverse array of challenges exists in the global campaign to address the burden of oral cancer. such challenges have served as barriers to the early diagnosis and treatmen...

given limited health sources, how to make drgs (diagnosis related groups) more feasible is a big question in developing countries. this study contributes to the debate on how to bridge the pay-for-service and drgs during the transitional period of payment reform.from 2008 to 2012, 20740 patients with cirrhosis or duodenal ulcer disease were chosen as sample. using multiple linear regression ana...

background: sparganosis is caused by the invasion of spirometra sparganum into various tissues/organs. subcutaneous sparganosis can be diagnosed by biopsy , while visceral/cerebral sparganosis is not easy to be diagnosed. the diagnosis de-pends largely on the detection of specific anti-sparganum antibodies. t he specific-ity of the elisa could be increased by using s. mansoni sparganum excretor...

conclusions safe water supply and adequate sanitation and hygiene are the important routes for the control and prevention of cholera infection. results cholera is a rare disease in industrialized countries; but, is still common in other parts of the world, including the indian subcontinent, sub-saharan africa, and latin and central american countries (like haiti). symptoms begin with a sudden o...