As an alternative to the continual expression of transcriptional repressors to turn off genes after they have served their purpose, nature has developed epigenetic strategies that result in the covalent modification of DNA itself to induce heritable gene silencing. Mounting evidence supports the notion that once a genomic region has been targeted for silencing by acquisition of one or more cova...

The share of molecular hydrogen as a source “green energy” is currently significantly increasing. It proposed to use existing underground natural gas storage facilities store large volumes hydrogen. In Russia, depleted oil and fields (DOGFs) deep aquifers are used for storage. purpose this work was determine microbial diversity in DOGF by cultural 16S rRNA gene-based approaches the effect H2 on...

Kostmann disease is an inherited severe congenital neutropenia syndrome associated with loss-of-function mutations in an adaptor protein HS1-associated protein X-1 (Hax1). How Hax1 regulates neutrophil function remains largely unknown. In this paper, we use ribonucleic acid interference to deplete Hax1 in the neutrophil-like cell line PLB-985 and identify Hax1 as a negative regulator of integri...

Borrelia hermsii, a spirochete and an etiological agent of relapsing fever, was cultivated in modified Kelly medium. Studies of the action of penicillin on B. hermsii strain HS1 revealed the following: (i) the in vitro minimum inhibitory concentration and minimum bactericidal concentration of benzylpenicillin for this strain were 0.4 and 3.1 nmol/ml (0.15 and 1.1 micrograms/ml), respectively; (...