-Introduction: Hepatocellular carcinoma (HCC) develops against a background of cirrhosis by a multi-step dedifferentiation process from regenerative nodules to dysplastic nodules to HCC. Liver transplantation provides the most effective treatment for HCC providing the diagnosis is made at an early stage, but because the liver is structurally abnormal, HCC is often difficult to detect and distin...

OBJECTIVE This article reviews the different technical aspects and pitfalls of gadolinium (Gd)-ethoxibenzyl (EOB)-diethylenetriamine pentaacetic acid (DTPA) and the advantages of the hepatocellular phase (HCP) and defines its specific imaging features of liver lesions. BACKGROUND Gd-EOB-DTPA is a contrast agent with combined properties of a conventional non-specific extracellular and a hepato...

Hypothesis: Delayed Gd(DTPA) enhanced MRI of cartilage (dGEMRIC) is a method designed to image the distribution of fixed charge density in cartilage, based on the premise that mobile ions will distribute in cartilage in relation to the concentration of the charged glycosoaminoglycan (GAG) molecules. The hypothesis to be tested here is whether the variation of T1 values post-Gd is a true reflect...

OBJECTIVE In the literature, there are many reports comparing relative renal function calculated with Tc 99m DTPA and Tc 99m DMSA in adults and children. However, there is no consensus about the results. As there is indeterminacy in the reliability of Tc 99m DTPA for the calculation of the relative renal functions, we retrospectively designed a study to compare the relative renal functions meas...

In an effort to improve on the noninvasive detection of renal artery stenosis, we investigated the effect of angiotensin converting enzyme inhibition on computer-assisted 99mTc-diethylenetriaminepentaacetic acid (DTPA) renal flow studies in a canine model of two-kidney, one clip hypertension and compared these findings with clearances of inulin and p-aminohippuric acid in the stenotic and contr...

• Agents originally developed to enhance contrast-to-noise in anatomic images following intravenous administration. • Their principal mode of action is to increase the relaxation rates (1/T1, 1/T2, 1/T2*) of nearby water molecules thereby modifying local signal intensity. • Extracellular agents (such as Gd-DTPA) accumulate in the interstitium of many tissues (e.g. muscle) but do not cross the b...

The effect of several chelating agents (diethyldithiocarbamic acid, DDC; nitrilotriacetic acid, NTA; 2,3-dimercaptopropanol, BAL; d,l-penicillamine, PEN; 2,3-dimercaptosuccinic acid, DMSA; ethylenediaminetetraacetic acid, EDTA; and diethylenetriaminepentaacetic acid, DTPA) on the toxicity, distribution and excretion of cadmium (Cd) was determined in mice. When chelators were administered immedi...

BACKGROUND Two 99mTc-DTPA attached estrone derivatives were synthesized and their radiopharmaceutical potential was determined using female albino Wistar rats. MATERIALS AND METHODS Two novel radiolabeled estrone derivatives, 99mTc-2,2',2"2"'-(2,2'-(2-(3-methoxy-13-methyl-17-oxo-7, 8, 9, 11, 12, 13, 14, 15, 16, 7-decahydro-6H- cyclopenta[a]phenanthren-2-ylamino)-2- oxoethylazanediyl) bis(etha...

The objective of this study was to assess and compare the reactogenicity of GlaxoSmithKline (GSK) Biologicals' diphtheria-tetanus-tricomponent acellular pertussis vaccine (DTPa) and the locally used combined diphtheria-tetanus-whole-cell pertussis vaccine (DTPw) as a primary vaccination course in healthy infants at the age of 3, 4 and 5 months. A phase IV, single-blinded, randomized comparative...

BACKGROUND Novel potential MR imaging contrast agents Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd-TCP), Gd-hematoporphyrin (Gd-H), Gd-DTPA-9.2.27 against melanoma, Gd-DTPA-WM53 against leukemia and Gd-DTPA-C595 against breast cancer cells were synthesized and applied to mice with different human cancer cells (melanoma MM-138, leukemia HL-60, breast MCF-7). The relaxivity, the biodistribution...