During the growth of Penicillium stipitatum, stipitatonic acid was found to be the major component of the culture medium of young cultures, whereas stipitatic acid predominated in older cultures (3). This finding, and the easy chemical decarboxylation of stipitatonic acid to stipitatic acid in boiling water, suggested that the dicarboxylic acid was the precursor of the monocarboxylic acid. Furt...

Microwave irradiation is used in the synthesis of four tricyclic chromanones 11-14. The chromanone 14 and 12 are selectively formed thermally and under microwave in the presence of polyphosphoric acid (PPA) from the same dicarboxylic acid 9, respectively. The crystal structures of the two diacids are also reported. The corresponding ortho and meta isomers of diacids crystallize in the space...

In the title adduct, 2C(18)H(14)N(4)·C(8)H(6)O(4), the centrosymmetric 1,4-benzene-dicarboxylic acid mol-ecule makes two O-H⋯·N hydrogen bonds to adjacent 10,11,12,13-tetra-hydro-4,5,9,14-tetra-azadibenzo[a,c]anthracene (TTBT) mol-ecules. Aromatic π-π stacking inter-actions occur between TTBT rings [centroid-centroid distance = 3.570 (3) Å], leading to a two-dimensional supra-molecular structur...

During the growth of Penicillium stipitatum, stipitatonic acid was found to be the major component of the culture medium of young cultures, whereas stipitatic acid predominated in older cultures (3). This finding, and the easy chemical decarboxylation of stipitatonic acid to stipitatic acid in boiling water, suggested that the dicarboxylic acid was the precursor of the monocarboxylic acid. Furt...

Crystallization and multicomponent crystal formation of active pharmaceutical ingredients Baclofen Phenibut with dicarboxylic acid co-formers are discussed. The crystallization process several crystalline entities is elucidated via single crystal—as well as powder X-ray—diffraction, followed by thermal analysis phase stability studies over time. Both APIs form increasingly complex phases malic ...

Mammals express seven transporters from the SLC1 (solute carrier 1) gene family, including five acidic amino acid transporters (EAAT1-5) and two neutral amino acid transporters (ASCT1-2). In contrast, insects of the order Diptera possess only two SLC1 genes. In this work we show that in the mosquito Culex quinquefasciatus, a carrier of West Nile virus, one of its two SLC1 EAAT-like genes encode...

Coupling picolinic acid (pyridine-2-carboxylic acid) and pyridine-2,6-dicarboxylic acid with N-alkylanilines affords a range of mono- and bis-amides in good to moderate yields. These amides are of interest for potential applications in catalysis, coordination chemistry and molecular devices. The reaction of picolinic acid with thionyl chloride to generate the acid chloride in situ leads not onl...

The tensile properties of sulfonated polyoxadiazoles have been studied as a function of molecular weight and sulfonation level. All sulfonated polyoxadiazoles synthesized through a polycondensation reaction of the hydrazine sulphate salt and a dicarboxylic acid in poly(phosphoric acid) exhibit rigid-ductile behavior with high Young’s modulus (3-4 GPa) and with larger elongations at break (up to...

The title cocrystal, C(10)H(8)N(2)·C(6)H(6)O(4), crystallizes with half-mol-ecules of 4,4'-bipyridine and trans,trans-hexa-2,4-dienedioic acid in the asymmetric unit, as each is located about a crystallographic inversion center. The bipyridine molecule is planar from symmetry. In the dicarboxylic acid molecule, the O-C-C-C torsion angle is -13.0 (2)°. In the crystal, O-H⋯N and C-H⋯O hydrogen bo...

1.1 Materials Chromium nitrate nonahydrate (Cr(NO3)2·9H2O, 99%) and hydrofluoric acid (analysis grade) were obtained from Acros Organics. Benzene-1,4-dicarboxylic acid (H2BDC, 99%) was acquired from Aldrich. Dichloromethane (DCM, >99.9%), N,N-dimethylformamide (DMF, 99.9%) and Ethanol (99.9%) were purchased from Prolabo. Polysulfone (PSF) Ultason S 6010 Natural was provided by BASF AG, Ludwigsh...