OBJECTIVE To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications. RESEARCH DESIGN AND METHODS The study was conducted in 246 type 1 and 530 type 2 diabetic patients. The alleles of both polymorphisms were detected using PCR and subsequent cleavage by NcoI and HinfI restriction endonuclease...

In this review, an in-depth anatomic and molecular pathogenesis of diabetic neuropathy is provided. Classifications and clinical manifestations of diabetic neuropathy are discussed. The current modalities of treatment and clinical research on this disorder are summarized.

Background: Diabetes may cause a wide range of eye disorders, including cataracts, glaucoma and other ocular abnormalities, recurrent styes, non-arteritic anterior ischemic optic neuropathy diabetic papillopathy.

BACKGROUND AND AIMS Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN). METHODS...

Chronic diabetic neuropathy is associated with peripheral demyelination and degeneration of nerve fibers. The mechanism(s) underlying neuronal injury in diabetic sensory neuropathy remain poorly understood. Recently, we reported increased expression and function of transient receptor potential vanilloid 1 (TRPV1) in large dorsal root ganglion (DRG) neurons in diabetic sensory neuropathy. In thi...

Diabetic neuropathy is the most common long-term complication of Type 1 and Type 2 diabetes, affecting approximately 10% within a year of diagnosis to 50% of subjects with diabetes for more than 25 years. Prevalence rates depend on diagnostic technique and the population under study (Dahlin et al., 2011; Rubino et al., 2007). Diabetic neuropathy associated with Type 1 diabetes tend to be more f...

Abstract Background Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication common in neuropathy mainly due side effects and poor tolerance medication. Botulinum toxin A intradermal injection has proved efficacy cases of neuropathy, however there a need compare its effect other lines treatment. The aim the study was type versus conventional oral...

OBJECTIVE Functional cobalamin (Cbl) deficiency (i.e., high methylmalonic acid [MMA] values despite normal serum Cbl levels) is common in the elderly and associated with neuropathy and anemia. Because diabetes is also common in the elderly and diabetic neuropathy resembles that of Cbl deficiency, the role of diabetes in functional Cbl deficiency was explored. RESEARCH DESIGN AND METHODS A ret...