Type 1 diabetes is a complex metabolic disease involving multiple organ systems which may cause severe visual impairment. Almost all parts of the eye may be affected including: the extra-ocular muscles, intra-ocular lens, the optic nerve, and retina. Diabetes is the leading cause of blindness between the ages of 20 and 74 in many developed countries (Cheung et al., 2010; Powers, 2008). Individu...

Currently, no pharmacological therapies treat skeletal muscle insulin resistance in pathological conditions such as type 2 diabetes, age-associated diseases, and cancer. Therefore, there is an unmet need to identify the molecular mechanisms ...The events governing glucose uptake have potential for managing obesity, With current treatments target ...

Progress in developing treatments for diabetic neuropathy is slowed by our limited understanding of how disturbances in metabolic substrates - glucose and fatty acids - produce nerve injury. In this review, we present the current oxidative stress hypothesis and experimental data that support it. We identify weaknesses in our understanding of diabetes-disordered metabolism in the neurovascular u...

background & aim: diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. experimental: this study aimed at assessing ...

SUMMARY OBJECTIVE: Cardiovascular risk stratification is an important clinical practice to estimate the severity of cardiovascular disease in patients with type 2 diabetes. This study aimed compare global specific for diabetes, seen at specialized outpatient clinics, and evaluate possible differences diagnoses treatments. METHODS: A total 122 diabetes treated two from 2017 2019, were studied. T...

The prevalence of diabetes mellitus has increased astronomically in recent years. This resulted disease adjusted life years (DALYs), mortality and decrease expectancy. Some the fall outs diabetic patients include hyperlipidaemia, oxidative stress, renal hepatic dysfunction. study investigated combined effects metformin with either vitamin C or E on hyperglycemia-induced hyperlipidemia, Diabetes...

Diabetes mellitus is a chronic metabolic disease that results in high levels of glucose in the blood. Normally, glucose is transported into cells from the blood for energy, and this transport is initiated in response to the hormone, insulin. In diabetic patients, cellular glucose uptake is defective, in part due to the inability of cells to respond to insulin, or the inability of the body to pr...

With this issue, we launch Clinical Diabetes and Endocrinology (CDE), a new journal for health researchers and professionals involved in the care of people with diabetes and endocrine diseases. CDE is published collaboratively by the University of Michigan and our partners at BioMed Central. Our vision is to share new research and clinical knowledge in diabetes and endocrine diseases with the h...

OBJECTIVE To investigate diabetic patients' perceptions of illness and treatments, and explore relationships to adherence and blood glucose control. RESEARCH DESIGN AND METHODS Forty-nine type 1 and one hundred and eight type 2 diabetic patients completed questionnaires assessing illness perceptions, treatment beliefs, and adherence to medications, diet, and exercise. Blood glucose control wa...