estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

objective: serum leptin concentration reflects the body fat mass. there is controversial reports about the insulin effect on serum leptin concentration. we wanted to examine the effect of insulin therapy on serum leptin in children with new onset type i diabetes. materials and methods: this was a cross-sectional study in children's medical center on 34 children who had new onset type i dia...

An association between diabetes and periodontitis has been long suspected and has now been reasonably well documented for both type I insulin dependent diabetes mellitus and type II non insulin dependent diabetes mellitus. Diabetes mellitus is a systemic complication affecting both the quality and length of life. The interrelationship between periodontitis and diabetes provides an example of sy...

The system of IGF-I and its binding proteins may be involved in the pathogenesis of vascular damage in Type 1 diabetes. The aim of this study was to analyze the relationship between this system and the microvascular reactivity in Type 1 diabetes as measured by laser-Doppler flowmetry. Twenty-two Type 1 diabetic patients (13 women and 9 men) with microangiopathy and fifteen healthy subjects (8 w...

background: candidal colonization in complete denture wearers is a commonly encountered condition that worsens in the presence of untreated diabetes mellitus. the aim of this study was to evaluate the correlation between oral candidiasis in denture‑bearing mucosa and elevated blood glucose levels in complete denture wearers and to evaluate the effect of oral hypoglycemic drug therapy in control...

Background and Objectives: Type 2 diabetes is the most prevalent form of diabetes mellitus and is associated with a variety of complications. Homocysteine is an important independent risk factor for atherosclerotic diseases in both diabetic and non diabetic subjects. The association between these two is still unclear. The aim of this study was to assess the serum homocysteine levels in uncompli...