Di(2-ethylhexyl)-phthalate (DEHP) is the most abundantly used phthalate derivative, inevitable environmental exposure of which is suspected to contribute to the increasing incidence of testicular dysgenesis syndrome in humans. Oxidative stress and mitochondrial dysfunction in germ cells are suggested to contribute to phthalate-induced disruption of spermatogenesis in rodents, and Leydig cells a...

Several phthalate esters have been linked to the Phthalate Syndrome, affecting male reproductive development when administered to pregnant rats during in utero sexual differentiation. The goal of the current study was to enhance understanding of this class of compounds in the Sprague Dawley (SD) fetal rat following exposure on gestational days (GDs) 14-18 by determining the relative potency fac...

Total daily intakes of diethyl phthalate (DEP), di(n-butyl) phthalate (DnBP), di(isobutyl) phthalate (DiBP), butyl benzyl phthalate (BBzP) and di(2-ethylhexyl) phthalate (DEHP) were calculated from phthalate metabolite levels measured in the urine of 431 Danish children between 3 and 6 years of age. For each child the intake attributable to exposures in the indoor environment via dust ingestion...

Di(2-ethylhexyl) adipate [bis(2-ethylhexyl) adipate, DEHA, octyl adipate, dioctyl adipate, DOA, CAS No. 103-23-1], a plasticizer added to vinyl plastics to give low temperature flexibility, is dispersed (not bound) in the polymer chain matrix. Approved by the U.S. Food and Drug Administration for use in plastics that may contact nonfatty, nonalcoholic foods (not to exceed 24% by weight of the p...

BACKGROUND Phthalates have been identified as endocrine active compounds associated with developmental and reproductive toxicity. The exposure to phthalates in premenstrual Egyptian females remains unknown. The objective of this study was to characterize phthalate exposure of a potentially vulnerable population of premenstrual girls from urban and rural Egypt. MATERIALS AND METHODS We collect...

BACKGROUND Phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. OBJECTIVE This study was designed to assess long-term effects of maternal exposure to Di (2-ethylhexyl) Phthalate (DEHP) on reproductive ability of both neonatal and adult male offspring. MATERIALS AND METHODS 60 female rats randomly divided in four equal groups; vehicle control ...