نتایج جستجو برای: dhplc
تعداد نتایج: 390 فیلتر نتایج به سال:
human leukocytes cause activating mutations in the K-ras protooncogene. Nakajima T. K-ras gene point mutation in neo-genetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process. Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung ...
with the p.R110X mutation, as was described recently (13). Although p.R110X is one of the few recurrent mutations of this gene, we were unable to find other clinical descriptions of female patients carrying this mutation , and the movement disorder in CLS, although common, is not well studied. No clear hot spot mutations were found, thus highlighting the functional relevance of both protein kin...
BACKGROUND Transcript dosage imbalance may influence the transcriptome. To gain insight into the role of altered gene expression in hereditary colorectal polyposis predisposition, in the present study we analyzed absolute and allele-specific expression (ASE) of adenomatous polyposis coli (APC) and mutY Homolog (MUTYH) genes. METHODS We analyzed DNA and RNA extracted from peripheral blood mono...
Mutations of p53, a tumor suppressor gene, are known to be involved in the pathogenesis of a number of neoplasms. This study investigated the distribution of p53 mutations within both esophageal and gastric adenocarcinomas. The correlation between p53 mutations and an overexpression of p53, which has been reported by other researchers, was also explored. Samples were taken from 17 patients foll...
سرطان روده بزرگ یکی از معمولیترین بدخیمی¬های موجود درکشورهای توسعه یافته است که بعنوان سومین نوع سرطان منجر به مرگ در کشورهای غربی شناخته شده است. میزان شیوع سالیانه آن در انگلستان 3500 نفر و در کل دنیا نیم میلیون نفر تخمین زده می¬شود که معادل 13% کل سرطان¬ها می باشد. سالانه حدود 55000 نفر بخاطر سرطان روده بزرگ در ایالات متحده آمریکا می¬میرند. تخمین زده شده است که هر سال 19000 و 160000 مورد جدی...
Protocadherin X and Protocadherin Y (PCDHX and PCDHY) are cell-surface adhesion molecules expressed predominantly in the brain. The PCDHX/Y gene-pair was generated by an X-Y translocation approximately 3 million years ago (MYA) that gave rise to the Homo sapiens-specific region of Xq21.3 and Yp11.2 homology. Genes within this region are expected to code for sexually dimorphic human characterist...
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