Developmental examination is part of the process of identifying children at risk of poor developmental outcomes. Development is a rapidly changing process with large variations within the population and for the same child, which limits the sensitivity and specificity of any examination method. There is now a good body of scientific knowledge and an evidence base for improving the examination me...

The human auditory brainstem is thought to undergo rapid developmental changes early in life until age ∼2 followed by prolonged stability until aging-related changes emerge. However, earlier work on brainstem development was limited by sparse sampling across the lifespan and/or averaging across children and adults. Using a larger dataset than past investigations, we aimed to trace more subtle v...

objectives: there are various developmental screening tools that are different in terms of psychometric characteristics and choosing the best one is challenging for the pediatrician. this research was designed to identify the validity and reliability of parents evaluation of developmental status, a developmental screening questionnaire, in 4-60 months-old children in the city of tehran. methods...

Background Immune suppression is one of the hallmarks by which head and neck squamous cell carcinoma (HNSCC) develops a tumor permissible environment[1]. Semaphorin 4D (Sema4D), known for its various developmental, physiological and pathological effects, was recently shown to play a role in regulating the immune system[2]. Sema4D is expressed in many epithelial tumors including HNSCC[3]; yet, t...

Primary pulmonary hypertension (PPH) associated with pregnancy carries a high maternal mortality rate. Short-term epoprostenol infusion has been demonstrated to improve the hemodynamic profile in patients with PPH. We report a successful maternal-fetal outcome with epoprostenol therapy during pregnancy, cesarean section, and postpartum in a patient with PPH. Epoprostenol therapy did not produce...

Biologists make mistakes – but they can also find them and remedy them. I survey a series of cases where idealizations and assumptions about normality have shaped common erroneous biological concepts: male and female; developmental abnormalities; competition in evolution; and laws of nature. Such scientific interpretations of nature can have profound social consequences. Identifying such recurr...

PURPOSE Accurate description of an individual's communication status is critical in both research and practice. Describing the communication status of individuals with severe intellectual and developmental disabilities is difficult because these individuals often communicate with presymbolic means that may not be readily recognized. Our goal was to design a communication scale and summary score...

Heterotopic pancreas is an aberration in the developmental profile of the pancreas. This entity is rarely symptomatic and its malignant transformation is even rarer. However, when present, it poses a diagnostic dilemma to clinicians, as little help comes from gastroenteroscopy and imaging. Surgical exploration remains the only option at times, and it is the histopathological examination that fi...

Developmental, ideological, and behavioral characteristics of 58 convicted hate crime offenders were examined. Ratings on the Psychopathy Checklist: Screening Version, HCR-20, and Bias Motivation Profile (BMP) were made via record review. Offense characteristics were rated on the Cornell Aggression Index and Cormier-Lang Crime Index. Results indicated that offenders with higher BMP scores engag...

Finding reliable and valid ways to assess and profile developmental skills in children is an essential step in ultimately developing and providing effective and meaningful interventions. Measuring the effectiveness of intervention, comparing different intervention approaches and/or intensities and being able to predict the effect of additional risk and opportunity factors on children’s developm...