Disruption of sleep is a frequent complaint among elderly humans and is also evident in aged laboratory rodents. The neurobiological bases of age-related sleep/wake disruption are unknown. Given the critical role of the hypocretins in sleep/wake regulation, we sought to determine whether the wake-promoting effect of hypocretin changes with age in Wistar rats, a strain in which age-related chang...

User interface management systems (UIMSs) that support rapid prototyping often suffer from the limited range of interfaces that they can produce and the lack of support for the connection between the produced interface and its underlying application. This paper discusses a Mode Development Environment (MoDE) that addresses these problems.

Background Vessel wall imaging is commonly gated to alternate R-waves, in order to increase SNR and minimise artefacts due to RR-interval variation. In previous work with 2D carotid artery wall imaging, the resulting redundant RR-interval has been used to acquire additional parallel slices[1]. We postulate that the redundant RR-interval can be used to image an additional volume in 3D coronary a...